The Ordovician of North and West Africa comprises three main transgressive–regressive sequences understood as ‘second-order’ cycles of 10–15 myr duration. Tide- to wave-dominated shallow-marine clastic successions, preserving incidental bryozoan carbonates to the north, include fluvial deposits over the most proximal southern stretches of the platform. The boundary with Cambrian strata remains unclear but the latter are progressively less represented to the south in the undifferentiated ‘Cambro-Ordovician’. To the north, graptolites, brachiopods and trilobites combined with palynomorphs provide a robust biostratigraphic frame. Maximum flooding intervals occurred in the early to middle Tremadocian, middle Darriwilian and middle to late Katian. Two events interfered with an overall long-term transgressive trend. The ‘intra-Arenig’ (late Floian?) tectonic event highlighted palaeohighs coinciding with Paleoproterozoic basements. Gondwanan drainage basins were reorganized, which had an impact on sediment sourcing and distribution of detrital material (e.g. zircons) feeding the pre-Variscan Europe. The second event is the end-Ordovician glaciation. The domain supported the greatest part of the Hirnantian glaciers and may also have preserved pre-Hirnantian glacial archives. It is not until the very latest Ordovician that offshore conditions developed far inland; it is however suspected that this inundation benefited from a transient postglacial isostatic flexure.