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Article Dans Une Revue FEBS Journal Année : 2023

A novel optinEuRin stress connection in glaucoma

Résumé

The endoplasmic reticulum (ER) is the organelle where the production and shaping of most secreted and transmembrane proteins happens. ER function is finely regulated to prevent accumulation of misfolded proteins generating ER stress. ER stress is common in both healthy and pathological situations due to multiple intrinsic and extrinsic factors including acute demand in protein synthesis, hypoxia or impaired protein folding caused by gene mutations. Sayyad et al. found that the M98K mutation of optineurin sensitizes glaucoma retinal ganglion cells to ER stress-induced cell death. This is associated with an autophagy-dependent elevation of ER stress sensor expression.

Domaines

Cancer

Dates et versions

hal-04062149 , version 1 (07-04-2023)

Licence

Paternité

Identifiants

Citer

Elodie Lafont, Tony Avril. A novel optinEuRin stress connection in glaucoma. FEBS Journal, 2023, 290 (12), pp.3105-3109. ⟨10.1111/febs.16774⟩. ⟨hal-04062149⟩
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