In this work, the periodic homogenization method is applied to a system of two equations of diffusion coupled through heterogeneous chemical reactions at the solid-fluid interface. This upscaling is discussed according to the order of magnitude of the Damkohler number. For large values of Damkohler number, a new homogenized diffusion reaction model coupling chemical reaction and diffusion is obtained. The homogenized diffusion and co-diffusion tensors are function of the heterogeneous reaction rate coefficients. The relevance of this homogenized model is analysed with respect to the order of magnitude of the Damkohler number. Some numerical simulations using this homogenized model are carried out and compared to numerical simulations at pore scale.