Childhood exposure to non-persistent endocrine disrupting chemicals and multi-omic profiles: A panel study
Lorenzo Fabbri
(1, 2)
,
Ronan Garlantezec
(3, 4)
,
Karine Audouze
(5)
,
Mariona Bustamante
(1, 6, 2)
,
Ángel Carracedo
(7)
,
Leda Chatzi
(8)
,
Juan Ramón González
(1, 9)
,
Regina Grazuleviciene
(10)
,
Hector Keun
(11)
,
Chung-Ho E Lau
(11)
,
Eduard Sabidó
(6, 2)
,
Alexandros P. Siskos
(11)
,
Rémy Slama
(12, 13)
,
Cathrine Thomsen
(14)
,
John Wright
(15)
,
Wen Lun Yuan
(16, 17)
,
Maribel Casas
(1, 2)
,
M Vrijheid
(1, 2)
,
Léa Maitre
(1, 2)
1
ISGlobal -
Instituto de Salud Global - Institute For Global Health [Barcelona]
2 UPF - Universitat Pompeu Fabra [Barcelona]
3 Irset - Institut de recherche en santé, environnement et travail
4 EHESP - École des Hautes Études en Santé Publique [EHESP]
5 T3S - UMR_S 1124 - Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire
6 BIST - Barcelona Institute of Science and Technology
7 USC - Universidade de Santiago de Compostela [Spain]
8 Keck School of Medicine [Los Angeles]
9 UAB - Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona
10 VDU - Vytautas Magnus University - Vytauto Didziojo Universitetas
11 Imperial College London
12 INSERM - Institut National de la Santé et de la Recherche Médicale
13 IAB - Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)
14 NIPH - Norwegian Institute of Public Health [Oslo]
15 University of Bradford
16 A*STAR - Agency for science, technology and research [Singapore]
17 CRESS (U1153 / UMR_A 1125) - Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques
2 UPF - Universitat Pompeu Fabra [Barcelona]
3 Irset - Institut de recherche en santé, environnement et travail
4 EHESP - École des Hautes Études en Santé Publique [EHESP]
5 T3S - UMR_S 1124 - Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire
6 BIST - Barcelona Institute of Science and Technology
7 USC - Universidade de Santiago de Compostela [Spain]
8 Keck School of Medicine [Los Angeles]
9 UAB - Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona
10 VDU - Vytautas Magnus University - Vytauto Didziojo Universitetas
11 Imperial College London
12 INSERM - Institut National de la Santé et de la Recherche Médicale
13 IAB - Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)
14 NIPH - Norwegian Institute of Public Health [Oslo]
15 University of Bradford
16 A*STAR - Agency for science, technology and research [Singapore]
17 CRESS (U1153 / UMR_A 1125) - Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques
Ronan Garlantezec
- Fonction : Auteur
- PersonId : 181840
- IdHAL : ronan-garlantezec
- ORCID : 0000-0001-7420-6341
- IdRef : 115831649
Karine Audouze
- Fonction : Auteur
- PersonId : 1102728
Eduard Sabidó
- Fonction : Auteur
- PersonId : 1102023
Rémy Slama
- Fonction : Auteur
- PersonId : 11249
- IdHAL : remy-slama
- ORCID : 0000-0002-8980-8529
- IdRef : 088095169
Maribel Casas
- Fonction : Auteur
- PersonId : 1239181
- ORCID : 0000-0002-2112-6740
Léa Maitre
Connectez-vous pour contacter l'auteur
- Fonction : Auteur correspondant
- PersonId : 1106788
Connectez-vous pour contacter l'auteur
Résumé
Background: Individuals are exposed to environmental pollutants with endocrine disrupting activity (endocrine disruptors, EDCs) and the early stages of life are particularly susceptible to these exposures. Previous studies have focused on identifying molecular signatures associated with EDCs, but none have used repeated sampling strategy and integrated multiple omics. We aimed to identify multi-omic signatures associated with childhood exposure to non-persistent EDCs. Methods: We used data from the HELIX Child Panel Study, which included 156 children aged 6 to 11. Children were followed for one week, in two time periods. Twenty-two non-persistent EDCs (10 phthalate, 7 phenol, and 5 organophosphate pesticide metabolites) were measured in two weekly pools of 15 urine samples each. Multi-omic profiles (methylome, serum and urinary metabolome, proteome) were measured in blood and in a pool urine samples. We developed visit-specific Gaussian Graphical Models based on pairwise partial correlations. The visit-specific networks were then merged to identify reproducible associations. Independent biological evidence was systematically sought to confirm some of these associations and assess their potential health implications.Results: 950 reproducible associations were found among which 23 were direct associations between EDCs and omics. For 9 of them, we were able to find corroborating evidence from previous literature: DEP -serotonin, OXBE -cg27466129, OXBE -dimethylamine, triclosan -leptin, triclosan -serotonin, MBzP -Neu5AC, MEHP -cg20080548, oh-MiNP -kynurenine, oxo-MiNP -5-oxoproline. We used these associations to explore possible mechanisms between EDCs and health outcomes, and found links to health outcomes for 3 analytes: serotonin and kynurenine in relation to neuro-behavioural development, and leptin in relation to obesity and insulin resistance. Conclusions: This multi-omics network analysis at two time points identified biologically relevant molecular signatures related to non-persistent EDC exposure in childhood, suggesting pathways related to neurological and metabolic outcomes.
Domaines
Sciences du Vivant [q-bio]Format du dépôt | Fichier |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Childhood exposure to non-persistent endocrine disrupting chemicals and multi-omic profiles: A panel study
|
Résumé |
en
Background: Individuals are exposed to environmental pollutants with endocrine disrupting activity (endocrine disruptors, EDCs) and the early stages of life are particularly susceptible to these exposures. Previous studies have focused on identifying molecular signatures associated with EDCs, but none have used repeated sampling strategy and integrated multiple omics. We aimed to identify multi-omic signatures associated with childhood exposure to non-persistent EDCs. Methods: We used data from the HELIX Child Panel Study, which included 156 children aged 6 to 11. Children were followed for one week, in two time periods. Twenty-two non-persistent EDCs (10 phthalate, 7 phenol, and 5 organophosphate pesticide metabolites) were measured in two weekly pools of 15 urine samples each. Multi-omic profiles (methylome, serum and urinary metabolome, proteome) were measured in blood and in a pool urine samples. We developed visit-specific Gaussian Graphical Models based on pairwise partial correlations. The visit-specific networks were then merged to identify reproducible associations. Independent biological evidence was systematically sought to confirm some of these associations and assess their potential health implications.Results: 950 reproducible associations were found among which 23 were direct associations between EDCs and omics. For 9 of them, we were able to find corroborating evidence from previous literature: DEP -serotonin, OXBE -cg27466129, OXBE -dimethylamine, triclosan -leptin, triclosan -serotonin, MBzP -Neu5AC, MEHP -cg20080548, oh-MiNP -kynurenine, oxo-MiNP -5-oxoproline. We used these associations to explore possible mechanisms between EDCs and health outcomes, and found links to health outcomes for 3 analytes: serotonin and kynurenine in relation to neuro-behavioural development, and leptin in relation to obesity and insulin resistance. Conclusions: This multi-omics network analysis at two time points identified biologically relevant molecular signatures related to non-persistent EDC exposure in childhood, suggesting pathways related to neurological and metabolic outcomes.
|
Auteur(s) |
Lorenzo Fabbri
1, 2
, Ronan Garlantezec
3, 4
, Karine Audouze
5
, Mariona Bustamante
1, 6, 2
, Ángel Carracedo
7
, Leda Chatzi
8
, Juan Ramón González
1, 9
, Regina Grazuleviciene
10
, Hector Keun
11
, Chung-Ho E Lau
11
, Eduard Sabidó
6, 2
, Alexandros P. Siskos
11
, Rémy Slama
12, 13
, Cathrine Thomsen
14
, John Wright
15
, Wen Lun Yuan
16, 17
, Maribel Casas
1, 2
, M Vrijheid
1, 2
, Léa Maitre
1, 2
1
ISGlobal -
Instituto de Salud Global - Institute For Global Health [Barcelona]
( 533869 )
- Espagne
2
UPF -
Universitat Pompeu Fabra [Barcelona]
( 128785 )
- Plaça de la Mercè, 10-12 - 08002 Barcelona
- Espagne
3
Irset -
Institut de recherche en santé, environnement et travail
( 182194 )
- 263 avenue Général Leclerc 35042 Rennes Cedex
- France
4
EHESP -
École des Hautes Études en Santé Publique [EHESP]
( 301986 )
- 15, avenue du Pr. Léon Bernard - 35043 Rennes Cedex
- France
5
T3S - UMR_S 1124 -
Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire
( 1004846 )
- Centre Universitaire des Saints Pères - 45 Rue des Saints-Pères 75270 Paris Cedex 06
- France
6
BIST -
Barcelona Institute of Science and Technology
( 491770 )
- Carrer Comte d'Urgell, 187, 08036 Barcelona, Espagne
- Espagne
7
USC -
Universidade de Santiago de Compostela [Spain]
( 303469 )
- Praza do Obradoiro, 0, 15705 Santiago de Compostela, A Coruña, Espagne
- Espagne
8
Keck School of Medicine [Los Angeles]
( 308698 )
- 1975 Zonal Ave., Los Angeles, CA 90033
- États-Unis
9
UAB -
Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona
( 98227 )
- UAB Campus 08193 Bellaterra Barcelona
- Espagne
10
VDU -
Vytautas Magnus University - Vytauto Didziojo Universitetas
( 440320 )
- K. Donelaičio str. 58, 44248, Kaunas
- Lituanie
11
Imperial College London
( 69530 )
- South Kensington Campus, London SW7 2AZ
- Royaume-Uni
12
INSERM -
Institut National de la Santé et de la Recherche Médicale
( 303623 )
- 101, rue de Tolbiac, 75013 Paris
- France
13
IAB -
Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)
( 1043222 )
- Institut pour l'Avancée des Biosciences
Centre de Recherche UGA / Inserm U 1209 / CNRS UMR 5309
Site Santé - Allée des Alpes
38700 La Tronche
- France
14
NIPH -
Norwegian Institute of Public Health [Oslo]
( 92344 )
- PO Box 222 Skøyen
N-0213 Oslo
- Norvège
15
University of Bradford
( 458472 )
- Bradford BD7 1DP, England
- Royaume-Uni
16
A*STAR -
Agency for science, technology and research [Singapore]
( 301895 )
- Singapour
17
CRESS (U1153 / UMR_A 1125) -
Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques
( 1002409 )
- Hôtel-Dieu - 1 place du Parvis Notre-Dame - 75004 Paris
- France
|
Langue du document |
Anglais
|
Nom de la revue |
|
Volume |
173
|
Page/Identifiant |
-
|
Date de publication |
2023
|
Audience |
Internationale
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Licence |
Paternité - Pas d'utilisation commerciale - Pas de modification
|
Public visé |
Scientifique
|
Domaine(s) |
|
Financement |
|
Mots-clés |
en
Multi-omics, Metabolomics, Endocrine disruptors, Childhood
|
DOI | 10.1016/j.envint.2023.107856 |
Pubmed Id | 36867994 |
UT key WOS | 000948989800001 |
Origine :
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