This book is a reprint of articles from the Special Issue published online in the open access journal Journal of Personalized Medicine (ISSN 2075-4426). Extract from the preface by Anne-Marie Caminade : "The origin of this Special Issue about “Personalized and Precision Medicine 2022” of the Journal of Personalized Medicine is the International Conference on Personalized and Precision Medicine PEMED 2021, which occurred online on 7–9 April 2021, after three editions organized in Paris (25–27 June 2018), Barcelona (15–17 May 2019), and Munich (19–21 February 2020). The diversity of studies carried out in connection with personalized and precision medicine was clearly emphasized during these International Conferences, and is also observed in the 20 papers of this Special Issue. The most represented topics concern brain diseases, cancers, lungs obstruction, and muscles and skeletal diseases. Other topics concern in particular the intestinal microbiome or COVID-19, emerging methods for imaging and using radiotherapy, and a romising new class of therapeutic molecules, the dendrimers."