Article Dans Une Revue Science Année : 1999

Three-dimensional structures of the TAFII-containing complexes TFIID and TFTC

Résumé

TBP (TATA-binding protein)-associated factors (TAF(II)s) are components of large multiprotein complexes such as TFIID, TFTC, STAGA, PCAF/GCN5, and SAGA, which play a key role in the regulation of gene expression by RNA polymerase II. The structures of TFIID and TFTC have been determined at 3.5-nanometer resolution by electron microscopy and digital image analysis of single particles. Human TFIID resembles a macromolecular clamp that contains four globular domains organized around a solvent-accessible groove of a size suitable to bind DNA. TFTC is larger and contains five domains, four of which are similar to TFIID.

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hal-04057128 , version 1 (03-04-2023)

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Marjorie Brand, Claire Leurent, Véronique Mallouh, Laszlo Tora, Patrick Schultz. Three-dimensional structures of the TAFII-containing complexes TFIID and TFTC. Science, 1999, 286 (5447), pp.2151-2153. ⟨10.1126/science.286.5447.2151⟩. ⟨hal-04057128⟩
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