Exploring F/CF3 substituted oxocarbenium ions for the diastereoselective assembly of highly substituted tetrahydrofurans
Résumé
We report on the dramatic effect of a local partial charge inversion by replacing a CHCH3 group by a CFCF3 . This strategy allows the diastereoselective reduction of 5-membered ring oxocarbenium ions to access highly substituted tetrahydrofurans.
Domaines
Chimie organique
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Article Thibaudeau Leroux revised version_HAL.pdf (797.05 Ko)
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