<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-04044463</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-24T12:43:52+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">The multimodal connectivity of the hippocampal complex in auditory and visual hallucinations</title>
            <author role="aut">
              <persName>
                <forename type="first">A</forename>
                <surname>Amad</surname>
              </persName>
              <idno type="halauthorid">2767496-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Arnaud</forename>
                <surname>Cachia</surname>
              </persName>
              <email type="md5">2df313b7a50229b1307149778f7f3ca0</email>
              <email type="domain">gmail.com</email>
              <idno type="idhal" notation="string">arnaud-cachia</idno>
              <idno type="idhal" notation="numeric">735087</idno>
              <idno type="halauthorid" notation="string">7934-735087</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2125-4985</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.com/citations?user=Hqn-nyIAAAAJ&amp;hl=fr&amp;oi=ao</idno>
              <idno type="IDREF">https://www.idref.fr/085263915</idno>
              <affiliation ref="#struct-1004798"/>
              <affiliation ref="#struct-1004695"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">P</forename>
                <surname>Gorwood</surname>
              </persName>
              <idno type="halauthorid">2767497-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">D</forename>
                <surname>Pins</surname>
              </persName>
              <idno type="halauthorid">2767498-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">C</forename>
                <surname>Delmaire</surname>
              </persName>
              <idno type="halauthorid">510096-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">B</forename>
                <surname>Rolland</surname>
              </persName>
              <email type="md5">9105ec849fe8d8c8fadcf0dede851624</email>
              <email type="domain">gmail.com</email>
              <idno type="idhal" notation="string">benjamin-rolland</idno>
              <idno type="idhal" notation="numeric">1036725</idno>
              <idno type="halauthorid" notation="string">1670443-1036725</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8666-3635</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">M</forename>
                <surname>Mondino</surname>
              </persName>
              <email type="md5">f025906f8206dbbc12532ab36068b30d</email>
              <email type="domain">ch-le-vinatier.fr</email>
              <idno type="idhal" notation="string">marine-mondino</idno>
              <idno type="idhal" notation="numeric">752688</idno>
              <idno type="halauthorid" notation="string">2767499-752688</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-3175-8503</idno>
              <idno type="IDREF">https://www.idref.fr/183591372</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">P</forename>
                <surname>Thomas</surname>
              </persName>
              <idno type="halauthorid">704453-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">R</forename>
                <surname>Jardri</surname>
              </persName>
              <email type="md5">95a6fb76869aa51508b17b36eb9d828e</email>
              <email type="domain">gmail.com</email>
              <idno type="idhal" notation="string">760461</idno>
              <idno type="idhal" notation="numeric">760461</idno>
              <idno type="halauthorid" notation="string">2767500-760461</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4596-1502</idno>
              <idno type="IDREF">https://www.idref.fr/113055536</idno>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Arnaud</forename>
                <surname>Cachia</surname>
              </persName>
              <email type="md5">2df313b7a50229b1307149778f7f3ca0</email>
              <email type="domain">gmail.com</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2023-03-24 11:37:52</date>
              <date type="whenModified">2025-02-13 15:19:42</date>
              <date type="whenReleased">2023-03-24 11:37:52</date>
              <date type="whenProduced">2014-02</date>
              <ref type="externalLink" target="https://www.nature.com/articles/mp2012181.pdf"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="80995">
                <persName>
                  <forename>Arnaud</forename>
                  <surname>Cachia</surname>
                </persName>
                <email type="md5">2df313b7a50229b1307149778f7f3ca0</email>
                <email type="domain">gmail.com</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-04044463</idno>
            <idno type="halUri">https://hal.science/hal-04044463</idno>
            <idno type="halBibtex">amad:hal-04044463</idno>
            <idno type="halRefHtml">&lt;i&gt;Molecular Psychiatry&lt;/i&gt;, 2014, 19 (2), pp.184-191. &lt;a target="_blank" href="https://dx.doi.org/10.1038/mp.2012.181"&gt;&amp;#x27E8;10.1038/mp.2012.181&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Molecular Psychiatry, 2014, 19 (2), pp.184-191. &amp;#x27E8;10.1038/mp.2012.181&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UP-SANTE">Université Paris Cité - Faculté de Santé</idno>
            <idno type="stamp" n="UP-SOCIETES-HUMANITES">Université Paris Cité - Faculté Sociétés et Humanités</idno>
            <idno type="stamp" n="LAPSYDE">Laboratoire de Psychologie du Développement et de l'Éducation de l'enfant</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">The multimodal connectivity of the hippocampal complex in auditory and visual hallucinations</title>
                <author role="aut">
                  <persName>
                    <forename type="first">A</forename>
                    <surname>Amad</surname>
                  </persName>
                  <idno type="halauthorid">2767496-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Arnaud</forename>
                    <surname>Cachia</surname>
                  </persName>
                  <email type="md5">2df313b7a50229b1307149778f7f3ca0</email>
                  <email type="domain">gmail.com</email>
                  <idno type="idhal" notation="string">arnaud-cachia</idno>
                  <idno type="idhal" notation="numeric">735087</idno>
                  <idno type="halauthorid" notation="string">7934-735087</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2125-4985</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.com/citations?user=Hqn-nyIAAAAJ&amp;hl=fr&amp;oi=ao</idno>
                  <idno type="IDREF">https://www.idref.fr/085263915</idno>
                  <affiliation ref="#struct-1004798"/>
                  <affiliation ref="#struct-1004695"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">P</forename>
                    <surname>Gorwood</surname>
                  </persName>
                  <idno type="halauthorid">2767497-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">D</forename>
                    <surname>Pins</surname>
                  </persName>
                  <idno type="halauthorid">2767498-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">C</forename>
                    <surname>Delmaire</surname>
                  </persName>
                  <idno type="halauthorid">510096-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">B</forename>
                    <surname>Rolland</surname>
                  </persName>
                  <email type="md5">9105ec849fe8d8c8fadcf0dede851624</email>
                  <email type="domain">gmail.com</email>
                  <idno type="idhal" notation="string">benjamin-rolland</idno>
                  <idno type="idhal" notation="numeric">1036725</idno>
                  <idno type="halauthorid" notation="string">1670443-1036725</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8666-3635</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">M</forename>
                    <surname>Mondino</surname>
                  </persName>
                  <email type="md5">f025906f8206dbbc12532ab36068b30d</email>
                  <email type="domain">ch-le-vinatier.fr</email>
                  <idno type="idhal" notation="string">marine-mondino</idno>
                  <idno type="idhal" notation="numeric">752688</idno>
                  <idno type="halauthorid" notation="string">2767499-752688</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3175-8503</idno>
                  <idno type="IDREF">https://www.idref.fr/183591372</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">P</forename>
                    <surname>Thomas</surname>
                  </persName>
                  <idno type="halauthorid">704453-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">R</forename>
                    <surname>Jardri</surname>
                  </persName>
                  <email type="md5">95a6fb76869aa51508b17b36eb9d828e</email>
                  <email type="domain">gmail.com</email>
                  <idno type="idhal" notation="string">760461</idno>
                  <idno type="idhal" notation="numeric">760461</idno>
                  <idno type="halauthorid" notation="string">2767500-760461</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4596-1502</idno>
                  <idno type="IDREF">https://www.idref.fr/113055536</idno>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">17191</idno>
                <idno type="issn">1359-4184</idno>
                <idno type="eissn">1476-5578</idno>
                <title level="j">Molecular Psychiatry</title>
                <imprint>
                  <publisher>Nature Publishing Group</publisher>
                  <biblScope unit="volume">19</biblScope>
                  <biblScope unit="issue">2</biblScope>
                  <biblScope unit="pp">184-191</biblScope>
                  <date type="datePub">2014-02</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1038/mp.2012.181</idno>
              <idno type="pubmed">23318999</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="mesh">Adult</classCode>
              <classCode scheme="mesh">Antipsychotic Agents</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">Magnetic Resonance Imaging</classCode>
              <classCode scheme="mesh">Male</classCode>
              <classCode scheme="mesh">Nerve Fibers, Myelinated</classCode>
              <classCode scheme="mesh">Neural Pathways</classCode>
              <classCode scheme="mesh">Prefrontal Cortex</classCode>
              <classCode scheme="mesh">Rest</classCode>
              <classCode scheme="mesh">Schizophrenia</classCode>
              <classCode scheme="mesh">Thalamus</classCode>
              <classCode scheme="mesh">Visual Pathways</classCode>
              <classCode scheme="mesh">Auditory Perception</classCode>
              <classCode scheme="mesh">Visual Perception</classCode>
              <classCode scheme="mesh">Brain</classCode>
              <classCode scheme="mesh">Brain Mapping</classCode>
              <classCode scheme="mesh">Caudate Nucleus</classCode>
              <classCode scheme="mesh">Diffusion Magnetic Resonance Imaging</classCode>
              <classCode scheme="mesh">Female</classCode>
              <classCode scheme="mesh">Hallucinations</classCode>
              <classCode scheme="mesh">Hippocampus</classCode>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Hallucinations constitute one of the most representative and disabling symptoms of schizophrenia. Several Magnetic Resonance Imaging (MRI) findings support the hypothesis that distinct patterns of connectivity, particularly within networks involving the hippocampal complex (HC), could be associated with different hallucinatory modalities. The aim of this study was to investigate HC connectivity as a function of the hallucinatory modality, that is, auditory or visual. Two carefully selected subgroups of schizophrenia patients with only auditory hallucinations (AH) or with audio-visual hallucinations (A+VH) were compared using the following three complementary multimodal MRI methods: resting state functional MRI, diffusion MRI and structural MRI were used to analyze seed-based Functional Connectivity (sb-FC), Tract-Based Spatial Statistics (TBSS) and shape analysis, respectively. Sb-FC was significantly higher between the HC, the medial prefrontal cortex (mPFC) and the caudate nuclei in A+VH patients compared with the AH group. Conversely, AH patients exhibited a higher sb-FC between the HC and the thalamus in comparison with the A+VH group. In the A+VH group, TBSS showed specific higher white matter connectivity in the pathways connecting the HC with visual areas, such as the forceps major and the inferior-fronto-occipital fasciculus than in the AH group. Finally, shape analysis showed localized hippocampal hypertrophy in the A+VH group. Functional results support the fronto-limbic dysconnectivity hypothesis of schizophrenia, while specific structural findings indicate that plastic changes are associated with hallucinations. Together, these results suggest that there are distinct connectivity patterns in patients with schizophrenia that depend on the sensory-modality, with specific involvement of the HC in visual hallucinations.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-1004798" status="VALID">
          <idno type="IdRef">204082870</idno>
          <idno type="RNSR">201220454K</idno>
          <idno type="ROR">023kqz006</idno>
          <orgName>Laboratoire de psychologie du développement et de l'éducation de l'enfant</orgName>
          <orgName type="acronym">LaPsyDÉ - UMR 8240</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Labo A. Binet 46, rue Saint Jacques75005 PARIS</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.lapsyde.com/</ref>
          </desc>
          <listRelation>
            <relation name="UMR8240" active="#struct-441569" type="direct"/>
            <relation active="#struct-557826" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1004695" status="VALID">
          <idno type="RNSR">200816530M</idno>
          <orgName>Institut de psychiatrie et neurosciences de Paris</orgName>
          <orgName type="acronym">IPNP - U1266 Inserm</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>102-108 Rue de la Santé75014 PARIS</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://ipnp.paris5.inserm.fr//</ref>
          </desc>
          <listRelation>
            <relation name="U1266" active="#struct-303623" type="direct"/>
            <relation name="UMR-S 1266" active="#struct-557826" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-557826" status="VALID">
          <idno type="IdRef">236453505</idno>
          <idno type="ISNI">0000 0004 7885 7602</idno>
          <idno type="ROR">https://ror.org/05f82e368</idno>
          <orgName>Université Paris Cité</orgName>
          <orgName type="acronym">UPCité</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>85 boulevard Saint-Germain75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://u-paris.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>