We study the homogenization limit of the renewal equation with heterogeneous ex- ternal constraints by means of the two-scale convergence theory. We prove that the homogenized limit satisfies an equation involving non-local terms, which are the consequence of the oscillations in the birth and death terms. We have moreover shown that the numerical approximation of the homogenized equation via the two-scale limit gives an alternative way for the numerical study of the solution of the limiting problem.