Objectives: The primary objective of this 1-year pilot study was to evaluate the effectiveness of a depression self-management support group among primary care patients with depressive symptoms. A secondary objective was to determine its impact on antidepressant adherence, knowledge about depression, self-efficacy and self-management behaviors. The third objective was to assess for acceptability and feasibility. Methods: Using a pre- and post-intervention prospective design, 40 patients with depressive symptoms received a weekly self-management group intervention lasting 10 weeks. Inclusion criteria were: a) ≥ 18 years old; b) major depressive episode in the previous two years, based on the SCID; c) score ≥ 6 to Quick Inventory of Depressive Symptomatology-Clinician (QIDS-C) and ≥ 8 to Hamilton Rating Scale for Depression (HDRS). Exclusion criteria were: a) bipolar disorder; b) psychotic disorder; c) pregnancy or ≤ six months postpartum. Clinicians blind to the intervention completed pre-intervention and post-intervention telephone interviews assessing participants’ depressive symptomatology (QIDS and HDRS) and antidepressant adherence (MMAS). Knowledge about depression, self-efficacy and self-management behaviors were measured by self-administered questionnaires. Participant satisfaction and perceived usefulness of the intervention were also evaluated at post-intervention. Results: Participants had significantly lower levels of depressive symptoms after the group intervention. Self-management behaviors also improved. Based on these findings, patients’ feedback and rates of retention, the self-management support group intervention was acceptable. Feasibility is high because our recruitment was quicker than expected. Conclusion: Providing self-management support to depressive patients seems to be a promising intervention in primary care. A randomized controlled trial is needed before we can recommend implementing the program.