The intensive use of pesticides in agriculture generates a contamination of surface water and groundwater. However, conventional methods used in wastewater treatment plant remain partially effective for persistent organic pollutants (POPs). Advanced oxidation processes are implemented to degrade these pollutants. This research deals with the degradation by non- thermal plasma process of the micro-polluants present in the water. This plasma process produces in situ highly oxidizing species able to treat organic compounds. The objective of this study is to compare the treatment of a target molecule: Chlortoluron using two kinds of reactor: a plasma jet and a plasma Glidarc. For this, qualitative and quantitative analyses of the treated solutions were carried out. The preliminary results show the effectiveness of the plasma process for the treatment and degradation of chlortoluron with very close efficiencies for the two reactors. Thus, the continuation of this research aims at improving the performance of the reactors and to optimize the analysis methods in order to obtain more reliable and more precise outcomes.