Article Dans Une Revue Journal of Parkinson's Disease Année : 2022

Video-Based Automated Assessment of Movement Parameters Consistent with MDS-UPDRS III in Parkinson's Disease

Gaëtan Vignoud
  • Fonction : Auteur
Clément Desjardins
  • Fonction : Auteur
Quentin Salardaine
  • Fonction : Auteur
Marie Mongin
  • Fonction : Auteur
Béatrice Garcin
  • Fonction : Auteur
  • PersonId : 1121938
  • IdRef : 115220321
Bertrand Degos
  • Fonction : Auteur

Résumé

BACKGROUND: Among motor symptoms of Parkinson's disease (PD), including rigidity and resting tremor, bradykinesia is a mandatory feature to define the parkinsonian syndrome. MDS-UPDRS III is the worldwide reference scale to evaluate the parkinsonian motor impairment, especially bradykinesia. However, MDS-UPDRS III is an agent-based score making reproducible measurements and follow-up challenging. OBJECTIVE: Using a deep learning approach, we developed a tool to compute an objective score of bradykinesia based on the guidelines of the gold-standard MDS-UPDRS III. METHODS: We adapted and applied two deep learning algorithms to detect a two-dimensional (2D) skeleton of the hand composed of 21 predefined points, and transposed it into a three-dimensional (3D) skeleton for a large database of videos of parkinsonian patients performing MDS-UPDRS III protocols acquired in the Movement Disorder unit of Avicenne University Hospital. RESULTS: We developed a 2D and 3D automated analysis tool to study the evolution of several key parameters during the protocol repetitions of the MDS-UPDRS III. Scores from 2D automated analysis showed a significant correlation with gold-standard ratings of MDS-UPDRS III, measured with coefficients of determination for the tapping (0.609) and hand movements (0.701) protocols using decision tree algorithms. The individual correlations of the different parameters measured with MDS-UPDRS III scores carry meaningful information and are consistent with MDS-UPDRS III guidelines. CONCLUSION: We developed a deep learning-based tool to precisely analyze movement parameters allowing to reliably score bradykinesia for parkinsonian patients in a MDS-UPDRS manner.

Dates et versions

hal-04028432 , version 1 (14-03-2023)

Identifiants

Citer

Gaëtan Vignoud, Clément Desjardins, Quentin Salardaine, Marie Mongin, Béatrice Garcin, et al.. Video-Based Automated Assessment of Movement Parameters Consistent with MDS-UPDRS III in Parkinson's Disease. Journal of Parkinson's Disease, 2022, 12 (7), pp.2211--2222. ⟨10.3233/JPD-223445⟩. ⟨hal-04028432⟩
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