The education challenges at present times include the incorporation of information and communication technologies (ICT) in the learning-teaching process. In Higher Education the agreement between the volume of information to be processed by the student, the available student’s time and the assimilation of the courses contents is very important. The new study plans in Cuban Universities include the reduction of the number of face to face hours and the increase of the available time for the student’s independent study. Then, it is necessary to develop abilities that upgrade learning capacity during a lifetime through the self-education. The first version of a course on chemistry for radiochemistry students using the platform Moodle and Open Educational Resources (OER) as a support to the undergraduate course is presented. The detailed topic plan of the course of chemistry for radiochemists, which was distributed week by week, and different activities combining communication, interactive and collaborative modules were implemented on the platform Moodle. The whole system was tested during the first semester of the 2010-2011 academic year. The course evaluation results were carried out through a survey among the students and discussion forums. The results showed a good acceptance by the students, a better efficiency in the teaching-learning process given by better planning of the individual study, a better preparation to perform the laboratory practices, the new possibilities of communication between students and teachers, the access to OER and greater self-conscious of the students on their own process of learning.