Prognostic value of cerebral tissue oxygen saturation during neonatal extracorporeal membrane oxygenation - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue PLoS ONE Année : 2017

Prognostic value of cerebral tissue oxygen saturation during neonatal extracorporeal membrane oxygenation

Marie-Philippine Clair
  • Fonction : Auteur
Jérôme Rambaud
  • Fonction : Auteur
Adrien Flahault
  • Fonction : Auteur
Romain Guedj
  • Fonction : Auteur
Julia Guilbert
  • Fonction : Auteur
Isabelle Guellec
  • Fonction : Auteur
Amélie Durandy
  • Fonction : Auteur
Maryne Demoulin
  • Fonction : Auteur
Sandrine Jean
  • Fonction : Auteur
François Chalard
  • Fonction : Auteur
Chiara Sileo
  • Fonction : Auteur
Ricardo Carbajal
  • Fonction : Auteur
Sylvain Renolleau
  • Fonction : Auteur
Pierre-Louis Léger

Résumé

Objectives Extracorporeal membrane oxygenation support is indicated in severe and refractory respiratory or circulatory failures. Neurological complications are typically represented by acute ischemic or hemorrhagic lesions, which induce higher morbidity and mortality. The primary goal of this study was to assess the prognostic value of cerebral tissue oxygen saturation (StcO 2) on mortality in neonates and young infants treated with ECMO. A secondary objective was to evaluate the association between StcO 2 and the occurrence of cerebral lesions. Study design This was a prospective study in infants < 3 months of age admitted to a pediatric intensive care unit and requiring ECMO support. Measurements The assessment of cerebral perfusion was made by continuous StcO 2 monitoring using near-infrared spectroscopy (NIRS) sensors placed on the two temporo-parietal regions. Neurological lesions were identified by MRI or transfontanellar echography. Results Thirty-four infants <3 months of age were included in the study over a period of 18 months. The ECMO duration was 10±7 days. The survival rate was 50% (17/34 patients), and the proportion of brain injuries was 20% (7/34 patients). The mean StcO 2 during ECMO in the non-survivors was reduced in both hemispheres (p = 0.
Fichier principal
Vignette du fichier
Clair 2017 PloS One.pdf (683.49 Ko) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04026087 , version 1 (13-03-2023)

Identifiants

Citer

Marie-Philippine Clair, Jérôme Rambaud, Adrien Flahault, Romain Guedj, Julia Guilbert, et al.. Prognostic value of cerebral tissue oxygen saturation during neonatal extracorporeal membrane oxygenation. PLoS ONE, 2017, 12 (3), pp.e0172991. ⟨10.1371/journal.pone.0172991⟩. ⟨hal-04026087⟩
5 Consultations
4 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More