Understanding genomic instability induced by telomere shortering - Archive ouverte HAL Accéder directement au contenu
Communication Dans Un Congrès Année : 2021

Understanding genomic instability induced by telomere shortering

Résumé

Telomeres protect chromosomes from fusion and degradations, but this function is threatened in human somatic cells where telomeres are progressively shortened after successive cell divisions in the absence of telomerase activity. When telomeres are critically short, cells enter replicative senescence, in which the combined actions of the DNA damage signaling pathway, the DNA repair pathway, and mitosis mechanisms, can occasionally cause genomic instability and initiate oncogenesis. A difficulty associated with the study of mechanisms involved in genomic instability is the variability in telomere length, the intercellular variation in replicative senescence and the rarity of pathological events. The objective of this project is to study the initiation, expansion and consequences of genomic instability induced by telomere erosion. To circumvent the heterogeneity of genomic instability caused by telomere erosion, we are using a tool derived from CRISPR-Cas9 technology to generate telomeres of defined length in Saccharomyces cerevisiae. This tool will be used to study the global chromatin and epigenetic changes associated with telomere erosion that may contribute to the emergence of genomic instability.
Fichier non déposé

Dates et versions

hal-04023392 , version 1 (10-03-2023)

Identifiants

  • HAL Id : hal-04023392 , version 1

Citer

Maria Teresa Teixeira, Karine Casier. Understanding genomic instability induced by telomere shortering. 14th International Conference Levures, modèles et outils, Oct 2021, Strasbourg, France. ⟨hal-04023392⟩
11 Consultations
0 Téléchargements

Partager

Gmail Facebook X LinkedIn More