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Poster De Conférence Année : 2023

Recent developments & contribution to TAT of systems dedicated to α autoradiography

Résumé

One of the main difficulties in the development of TAT remains the difficulty of identifying and localizing the distribution of radiopharmaceuticals in the human body since the decay chain of the associated alpha emitter is generally composed of beta and alpha emitters which makes them difficult to localize accurately by techniques using gamma detection of the decays. To address the need to understand and quantify the spatial distribution of alpha emitting radiopharmaceuticals in tissues at high spatial resolution, important developments or improvements have been made in autoradiography systems. Indeed, as the first molecular imaging technique used for the localization of radiolabeled compounds in biological specimens, autoradiography remains the only technique that allows the imaging of charged particles with an unequalled spatial accuracy. In addition, the new generation of real-time counting imagers allow researchers to optimize acquisition time, have a very high sensitivity allowing the detection of short half-life radionuclides, offer the possibility to image in real time and quantify radioactive concentrations over a wide dynamic range. Moreover, their specific detection process allows the discrimination of several radionuclides in the same experiment and sometimes determine the equilibrium state of the radioactive chains. Nevertheless, as there are many types and configurations of detectors with various compromises in terms of activity quantification, spatial resolution, energy resolution and detection area, it remains complicated to be able to understand the different systems and their respective possibilities of evolution. This work therefore proposes to present the current and future applications of autoradiography and their associated detection systems.
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Dates et versions

hal-04019967 , version 1 (08-03-2023)

Identifiants

  • HAL Id : hal-04019967 , version 1

Citer

A. Bongrand, Laurine Puren, Melissa Azzoune, Samuel Duval, Jérôme Donnard, et al.. Recent developments & contribution to TAT of systems dedicated to α autoradiography. The 12th International Symposium on Targeted Alpha Therapy (TAT 12), Feb 2023, Cape Town, South Africa. . ⟨hal-04019967⟩
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