Interplay of Environmental, Individual and Genetic Factors in Rheumatoid Arthritis Provocation - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue (Article De Synthèse) International Journal of Molecular Sciences Année : 2022

Interplay of Environmental, Individual and Genetic Factors in Rheumatoid Arthritis Provocation

Marina Arleevskaya
Wesley Brooks
Marina Korovina
Andrey Novikov

Résumé

In this review, we explore systemization of knowledge about the triggering effects of non-genetic factors in pathogenic mechanisms that contribute to the development of rheumatoid arthritis (RA). Possible mechanisms involving environmental and individual factors in RA pathogenesis were analyzed, namely, infections, mental stress, sleep deprivation ecology, age, perinatal and gender factors, eating habits, obesity and smoking. The non-genetic factors modulate basic processes in the body with the impact of these factors being non-specific, but these common challenges may be decisive for advancement of the disease in the predisposed body at risk for RA. The provocation of this particular disease is associated with the presence of congenital loci minoris resistentia. The more frequent non-genetic factors form tangles of interdependent relationships and, thereby, several interdependent external factors hit one vulnerable basic process at once, either provoking or reinforcing each other. Understanding the specific mechanisms by which environmental and individual factors impact an individual under RA risk in the preclinical stages can contribute to early disease diagnosis and, if the factor is modifiable, might be useful for the prevention or delay of its development.
Fichier principal
Vignette du fichier
Arleevskaya_2022.pdf (12.92 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Licence : CC BY - Paternité

Dates et versions

hal-04019843 , version 1 (27-09-2023)

Licence

Paternité

Identifiants

Citer

Marina Arleevskaya, Elena Takha, Sergey Petrov, Gevorg Kazarian, Yves Renaudineau, et al.. Interplay of Environmental, Individual and Genetic Factors in Rheumatoid Arthritis Provocation. International Journal of Molecular Sciences, 2022, 23 (15), pp.8140. ⟨10.3390/ijms23158140⟩. ⟨hal-04019843⟩
73 Consultations
7 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More