Off-the-Shelf Gd(NO 3 ) 3 as an Efficient High-Spin Metal Ion Polarizing Agent for Magic Angle Spinning Dynamic Nuclear Polarization - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Physical Chemistry B Année : 2023

Off-the-Shelf Gd(NO 3 ) 3 as an Efficient High-Spin Metal Ion Polarizing Agent for Magic Angle Spinning Dynamic Nuclear Polarization

Stuart J Elliott
  • Fonction : Auteur
Benjamin B Duff
Ashlea R Taylor-Hughes
  • Fonction : Auteur
Daniel J Cheney
  • Fonction : Auteur
John P Corley
  • Fonction : Auteur
Subhradip Paul
Adam Brookfield
  • Fonction : Auteur
Shane Pawsey
  • Fonction : Auteur
David Gajan
Helen C Aspinall
  • Fonction : Auteur
Anne Lesage
Frédéric Blanc

Résumé

Magic angle spinning nuclear magnetic resonance spectroscopy experiments are widely employed in the characterization of solid media. The approach is incredibly versatile but deleteriously suffers from low sensitivity, which may be alleviated by adopting dynamic nuclear polarization methods, resulting in large signal enhancements. Paramagnetic metal ions such as Gd 3+ have recently shown promising results as polarizing agents for 1 H, 13 C, and 15 N nuclear spins. We demonstrate that the widely available and inexpensive chemical agent Gd(NO 3) 3 achieves significant signal enhancements for the 13 C and 15 N nuclear sites of [2-13 C, 15 N]glycine at 9.4 T and ∼105 K. Analysis of the signal enhancement profiles at two magnetic fields, in conjunction with electron paramagnetic resonance data, reveals the solid effect to be the dominant signal enhancement mechanism. The signal amplification obtained paves the way for efficient dynamic nuclear polarization without the need for challenging synthesis of Gd 3+ polarizing agents.

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Chimie
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Dates et versions

hal-04016881 , version 1 (06-03-2023)

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Citer

Stuart J Elliott, Benjamin B Duff, Ashlea R Taylor-Hughes, Daniel J Cheney, John P Corley, et al.. Off-the-Shelf Gd(NO 3 ) 3 as an Efficient High-Spin Metal Ion Polarizing Agent for Magic Angle Spinning Dynamic Nuclear Polarization. Journal of Physical Chemistry B, 2023, 126 (33), pp.6281-6289. ⟨10.1021/acs.jpcb.2c04184⟩. ⟨hal-04016881⟩
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