Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Cell Année : 1998

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions

Résumé

The mechanisms by which mutant huntingtin induces neurodegeneration were investigated using a cellular model that recapitulates features of neurodegeneration seen in Huntington's disease. When transfected into cultured striatal neurons, mutant huntingtin induces neurodegeneration by an apoptotic mechanism. Antiapoptotic compounds or neurotrophic factors protected neurons against mutant huntingtin. Blocking nuclear localization of mutant huntingtin suppressed its ability to form intranuclear inclusions and to induce neurodegeneration. However, the presence of inclusions did not correlate with huntingtin-induced death. The exposure of mutant huntingtin-transfected striatal neurons to conditions that suppress the formation of inclusions resulted in an increase in mutant huntingtin-induced death. These findings suggest that mutant huntingtin acts within the nucleus to induce neurodegeneration. However, intranuclear inclusions may reflect a cellular mechanism to protect against huntingtin-induced cell death.

Dates et versions

hal-04014360 , version 1 (03-03-2023)

Identifiants

Citer

Frédéric Saudou, Steven Finkbeiner, Didier Devys, Michael E. Greenberg. Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions. Cell, 1998, 95 (1), pp.55-66. ⟨10.1016/s0092-8674(00)81782-1⟩. ⟨hal-04014360⟩
11 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More