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              <p>ASICs (Acid-Sensing Ion Channels) constitute a family of excitatory cation channels activated by extracellular protons. They are widely expressed in pain pathways both in the peripheral nervous system (sensory neurons) and the central nervous system (spinal and supraspinal neurons). The ASIC3 channel, which is mainly expressed in peripheral sensory neurons, is also sensitive to lipids such as lysophosphatidylcholine (LPC). LPC increases the sensitivity of the channel to protons, generating activation at physiological pH as well as potentiation of its activity at acidic pH. The ability of LPC to activate/potentiate ASIC3, but also other channels expressed by sensory neurons and involved in pain such as TRPV1, TRPM8, TRPC5, or the K + channels TREK-1 and TRAAK, has highlighted the important role of this lipid in pain. Its effect is not limited to neurons and can affect other channels such as TRPV4 expressed in keratinocytes that also participate in sensory transduction. Elevated levels of LPC have pathophysiological consequences in pain that may involve these channels, including in humans, in fibromyalgia, rheumatic diseases, musculoskeletal disorders, or obesity (ASIC3), as well as in inflammatory and neuropathic pain (TRPC5) or in cholestatic pruritus (TRPV4).</p>
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              <p>Les ASIC ( Acid-Sensing Ion Channel ) forment une famille de canaux cationiques excitateurs activés par les protons extracellulaires. Ils sont largement exprimés dans les voies de la douleur au niveau du système nerveux périphérique (neurones sensoriels) et du système nerveux central (neurones spinaux et supraspinaux). Le canal ASIC3, qui est essentiellement exprimé dans les neurones sensoriels périphériques, est également sensible à des lipides comme la lysophosphatidylcholine (LPC). La LPC augmente la sensibilité du canal pour les protons, générant une activation à pH physiologique et une potentialisation de son activité à pH acide. La capacité de la LPC à activer/potentialiser ASIC3, mais aussi d’autres canaux exprimés par les neurones sensoriels et impliqués dans la douleur comme TRPV1, TRPM8, TRPC5 ou encore les canaux K + TREK-1 et TRAAK, a fait émerger le rôle important de ce lipide dans la douleur. Son effet ne se limite pas aux neurones et peut affecter d’autres canaux comme TRPV4 exprimé dans les kératinocytes qui participent également à la transduction sensorielle. Des niveaux élevés de la LPC ont des conséquences physiopathologiques dans la douleur pouvant impliquer ces canaux, y compris chez l’homme, dans la fibromyalgie, les maladies rhumatismales, les troubles musculosquelettiques ou l’obésité (ASIC3), mais aussi dans les douleurs inflammatoires et neuropathiques (TRPC5) ou dans le prurit cholestatique (TRPV4).</p>
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