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Article Dans Une Revue Biological Psychiatry Année : 2023

Are Brain Responses to Emotion a Reliable Endophenotype of Schizophrenia? An Image-Based Functional Magnetic Resonance Imaging Meta-analysis

André Aleman
  • Fonction : Auteur
Hengyi Cao
  • Fonction : Auteur
Raymond C.K. Chan
  • Fonction : Auteur
Asadur Chowdury
  • Fonction : Auteur
Patricia Conrod
  • Fonction : Auteur
Vaibhav Diwadkar
  • Fonction : Auteur
Vina Goghari
  • Fonction : Auteur
Salvador Guinjoan
  • Fonction : Auteur
Jun Soo Kwon
  • Fonction : Auteur
Johannes Lieslehto
  • Fonction : Auteur
Paulina Lukow
  • Fonction : Auteur
Andreas Meyer-Lindenberg
  • Fonction : Auteur
Gemma Modinos
  • Fonction : Auteur
Tiziana Quarto
  • Fonction : Auteur
Michael Spilka
  • Fonction : Auteur
Venkataram Shivakumar
  • Fonction : Auteur
Ganesan Venkatasubramanian
  • Fonction : Auteur
Mirta Villarreal
  • Fonction : Auteur
Yi Wang
  • Fonction : Auteur
Je-Yeon Yun
  • Fonction : Auteur

Résumé

Background: Impaired emotion processing constitutes a key dimension of schizophrenia and a possible endophenotype of this illness. Empirical studies consistently report poorer emotion recognition performance in patients with schizophrenia as well as in individuals at enhanced risk of schizophrenia. Functional magnetic resonance imaging studies also report consistent patterns of abnormal brain activation in response to emotional stimuli in patients, in particular, decreased amygdala activation. In contrast, brain-level abnormalities in at-risk individuals are more elusive. We address this gap using an image-based meta-analysis of the functional magnetic resonance imaging literature. Methods: Functional magnetic resonance imaging studies investigating brain responses to negative emotional stimuli and reporting a comparison between at-risk individuals and healthy control subjects were identified. Frequentist and Bayesian voxelwise meta-analyses were performed separately, by implementing a random-effect model with unthresholded group-level T-maps from individual studies as input. Results: In total, 17 studies with a cumulative total of 677 at-risk individuals and 805 healthy control subjects were included. Frequentist analyses did not reveal significant differences between at-risk individuals and healthy control subjects. Similar results were observed with Bayesian analyses, which provided strong evidence for the absence of meaningful brain activation differences across the entire brain. Region of interest analyses specifically focusing on the amygdala confirmed the lack of group differences in this region. Conclusions: These results suggest that brain activation patterns in response to emotional stimuli are unlikely to constitute a reliable endophenotype of schizophrenia. We suggest that future studies instead focus on impaired functional connectivity as an alternative and promising endophenotype.
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hal-04011481 , version 1 (02-03-2023)

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Anna Fiorito, André Aleman, Giuseppe Blasi, Josiane Bourque, Hengyi Cao, et al.. Are Brain Responses to Emotion a Reliable Endophenotype of Schizophrenia? An Image-Based Functional Magnetic Resonance Imaging Meta-analysis. Biological Psychiatry, 2023, 93 (2), pp.167-177. ⟨10.1016/j.biopsych.2022.06.013⟩. ⟨hal-04011481⟩
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