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Article Dans Une Revue Biological Psychiatry Année : 2023

Mindfulness Training Changes Brain Dynamics During Depressive Rumination: A Randomized Controlled Trial

Anne Maj van der Velden
Else-Marie Elmholdt
  • Fonction : Auteur
Lone O Fjorback
  • Fonction : Auteur
Catherine J Harmer
  • Fonction : Auteur
Sara W Lazar
  • Fonction : Auteur
Mia S O’toole
  • Fonction : Auteur
Jonathan Smallwood
  • Fonction : Auteur
Andreas Roepstorff
  • Fonction : Auteur

Résumé

BACKGROUND: Depression is a leading cause of disability worldwide and its prevalence is on the rise. One of the most debilitating aspects of depression is the dominance and persistence of depressive rumination, a state of mind that is linked to onset and recurrence of depression. Mindfulness meditation trains adaptive attention regulation and present-moment embodied awareness, skills that may be particularly useful during depressive mind states characterized by negative ruminative thoughts. METHODS: In a randomized controlled functional magnetic resonance imaging study (N = 80), we looked at the neurocognitive mechanisms behind mindfulness-based cognitive therapy (n = 50) for recurrent depression compared with treatment as usual (n = 30) across experimentally induced states of rest, mindfulness practice and rumination, and the relationship with dispositional psychological processes. RESULTS: Mindfulness-based cognitive therapy compared with treatment as usual led to decreased salience network connectivity to the lingual gyrus during a ruminative state, and this change in salience network connectivity mediated improvements in the ability to sustain and control attention to body sensations. CONCLUSIONS: These findings showed that a clinically effective mindfulness intervention modulates neurocognitive functioning during depressive rumination and the ability to sustain attention to the body.

Domaines

Neurosciences
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Origine : Publication financée par une institution

Dates et versions

hal-04011455 , version 1 (02-03-2023)

Identifiants

Citer

Anne Maj van der Velden, Jacqueline Scholl, Else-Marie Elmholdt, Lone O Fjorback, Catherine J Harmer, et al.. Mindfulness Training Changes Brain Dynamics During Depressive Rumination: A Randomized Controlled Trial. Biological Psychiatry, 2023, 93 (3), pp.233-242. ⟨10.1016/j.biopsych.2022.06.038⟩. ⟨hal-04011455⟩
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