Plasma nitriding is used to increase the durability of steels. The wettability of nitrided surfaces is poorly studied. The ability of nitriding in modifying the wetting and evaporation of sessile droplets on austenitic stainless steel is studied. Transferred plasma for nitriding provides independent substrate biasing giving the opportunity to tailor the surface before and during the nitriding treatments. It was shown that a cleaning treatment (Arsingle bondH2 plasma) produces topographical modifications of the surface by selective sputtering of the grains giving contact angles between 80 and 90°. Similar results are obtained when the nitriding treatments are carried out with a rather high bias voltage. It is explained using the skewness (Ssk) topographical roughness parameter which reveals the asymmetry of the profile. The more the Ssk is, the higher the contact angle is. During nitriding treatments, the very high internal stresses leads to the formation of spikes at the grain boundaries. Pinning of the three-phase contact line on peaks localized at grain boundaries are responsible for high contact angles. For nitriding treatments carried out with lower bias, surface contamination occurs and a discontinuous oxynitride layer is formed. The nanostructure formed by these oxides gives contact angles up to 120°.