Chemical reactions can lead to the expansion of the geomaterial because of the strong precipitation of minerals in the pores of the medium. The quantity and the variability of these reactions led to the development of several chemo-mechanical models. A generic chemo-poromechanical model is proposed to predict both the material degradation induced by various concrete pathologies and the environmental multi-factor impact on the macroscopic swelling. The model is based on the coupling between reactive transport (species diusion and chemical reactions) and poromechanics. The mineralogy and the poromechanical properties are estimated by a hydration-micromechanics model which allows to consider the material eects. The main applications are dedicated to External Sulfate Attack and Delayed Ettringite Formation of cementitious material at mesoscale. The studies highlight the ability of the model to deal with complex and various phenomena such as coupling chemical reactions with calcium leaching, sulfate sorption and ettringite precipitation, and to consider their impact on the macroscopic expansion. Results also bring out the accuracy of the chemo-poromechanical model to simulate dierent swelling pathologies. The characteristic crack paths induced by dierential strain, material impact, and swelling at the macroscopic scale, t with experimental observations.