Artificial Intelligence (AI) in healthcare promises to improve the accuracy of diagnosis and screening, support clinical care, and assist in various public health interventions such as disease surveillance, outbreak response, and health system management. But the increasing importance of AI in healthcare means that trustworthy AI is vital to achieve the beneficial impacts on health anticipated by both health professionals and patients. This book presents the proceedings of the 32nd Medical Informatics Europe Conference (MIE2022), organized by the European Federation for Medical Informatics (EFMI) and held from 27 - 30 May 2022 in Nice, France. The theme of the conference was Challenges of Trustable AI and Added-Value on Health. Over 400 submissions were received from 43 countries, and were reviewed in a thorough process by at least three reviewers before being assessed by an SPC co-chair, with papers requiring major revision undergoing further review. Included here are 147 full papers (acceptance rate 54%), 23 short papers and 79 posters from the conference. Topics covered include the usual sub-domains of biomedical informatics: decision support and clinical information systems; clinical research informatics; knowledge management and representation; consumer health informatics; natural language processing; public health informatics; and privacy, ethical and societal aspects, but also innovative approaches to the collection, such as organization and analysis of data and knowledge related to health and wellbeing, as well as theoretical and applied contributions to AI methods and algorithms. Providing an overview of the latest developments in medical informatics, the book will be of interest to all those involved in the development and provision of healthcare today.