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Chapitre D'ouvrage Année : 2021

Small Molecule Regulators of Ferroptosis

Résumé

Ferroptosis is a dedicated mode of cell death involving iron, reactive oxygen species and lipid peroxidation. Involved in processes such as glutathione metabolism, lysosomal iron retention or interference with lipid metabolism, leading either to activation or inhibition of ferroptosis. Given the implications of ferroptosis in diseases such as cancer, aging, Alzheimer and infectious diseases, new molecular mechanisms underlying ferroptosis and small molecules regulators that target those mechanisms have prompted a great deal of interest. Here, we discuss the current scenario of small molecules modulating ferroptosis and critically assess what is known about their mechanisms of action.
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Dates et versions

hal-04002220 , version 1 (23-02-2023)

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Sylvain Debieu, Stéphanie Solier, Ludovic Colombeau, Antoine Versini, Fabien Sindikubwabo, et al.. Small Molecule Regulators of Ferroptosis. Andrés F. Florez; Hamed Alborzinia. Ferroptosis: Mechanism and Diseases, 1301, Springer International Publishing, pp.81-121, 2021, Advances in Experimental Medicine and Biology, 978-3-030-62025-7. ⟨10.1007/978-3-030-62026-4_6⟩. ⟨hal-04002220⟩
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