Association between common cardiovascular risk factors and clinical phenotype in patients with hypertrophic cardiomyopathy from the European Society of Cardiology (ESC) EurObservational Research Programme (EORP) Cardiomyopathy/Myocarditis registry
Luis Lopes
,
Maria-Angela Losi
,
Nabeel Sheikh
,
Cécile Laroche
,
Philippe Charron
(1)
,
Juan Gimeno
,
Juan Kaski
,
Aldo Maggioni
,
Luigi Tavazzi
,
Eloisa Arbustini
,
Dulce Brito
,
Jelena Celutkiene
,
Albert Hagege
,
Ales Linhart
,
Jens Mogensen
,
José Manuel Garcia-Pinilla
,
Tomas Ripoll-Vera
,
Hubert Seggewiss
,
Eduardo Villacorta
,
Alida Caforio
,
Perry Elliott
,
Christopher Peter Gale
,
Branko Beleslin
,
Andrzej Budaj
,
Ovidiu Chioncel
,
Nikolaos Dagres
,
Nicolas Danchin
,
David Erlinge
,
Jonathan Emberson
,
Michael Glikson
,
Alastair Gray
,
Meral Kayikcioglu
,
Aldo Maggioni
,
Klaudia Vivien Nagy
,
Aleksandr Nedoshivin
,
Anna-Sonia Petronio
,
Jolien Roo Hesselink
,
Lars Wallentin
,
Uwe Zeymer
,
Alida Caforio
,
Juan Ramon Gimeno Blanes
,
Philippe Charron
,
Perry Elliott
,
Juan Pablo Kaski
,
Aldo Maggioni
,
Luigi Tavazzi
,
Michal Tendera
,
S Komissarova
,
N Chakova
,
S Niyazova
,
A Linhart
,
P Kuchynka
,
T Palecek
,
J Podzimkova
,
M Fikrle
,
E Nemecek
,
H Bundgaard
,
J Tfelt-Hansen
,
J Theilade
,
J Thune
,
A Axelsson
,
J Mogensen
,
F Henriksen
,
T Hey
,
S Nielsen
,
L Videbaek
,
S Andreasen
,
H Arnsted
,
A Saad
,
M Ali
,
J Lommi
,
T Helio
,
M Nieminen
,
Olivier Dubourg
,
N Mansencal
,
M Arslan
,
V Siam Tsieu
,
T Damy
,
A Guellich
,
S Guendouz
,
C Tissot
,
A Lamine
,
S Rappeneau
,
A Hagege
,
M Desnos
,
A Bachet
,
M Hamzaoui
,
Philippe Charron
(1)
,
Richard Isnard
,
L Legrand
,
C Maupain
,
E Gandjbakhch
,
M Kerneis
,
J-F Pruny
,
A Bauer
,
B Pfeiffer
,
Stephan Felix
,
Marcus Dörr
,
S Kaczmarek
,
Kristin Lehnert
,
A-L Pedersen
,
D Beug
,
M Bruder
,
M Böhm
,
I Kindermann
,
Y Linicus
,
C Werner
,
B Neurath
,
M Schild-Ungerbuehler
,
H Seggewiss
,
B Pfeiffer
,
A Neugebauer
,
P Mckeown
,
A Muir
,
J Mcosker
,
T Jardine
,
G Divine
,
P Elliott
,
M Lorenzini
,
O Watkinson
,
E Wicks
,
H Iqbal
,
S Mohiddin
,
C O'Mahony
,
N Sekri
,
G Carr-White
,
T Bueser
,
R Rajani
,
L Clack
,
J Damm
,
S Jones
,
R Sanchez-Vidal
,
M Smith
,
T Walters
,
K Wilson
,
S Rosmini
,
A Anastasakis
,
K Ritsatos
,
V Vlagkouli
,
T Forster
,
R Sepp
,
J Borbas
,
V Nagy
,
A Tringer
,
K Kakonyi
,
L Szabo
,
M Maleki
,
F Noohi Bezanjani
,
A Amin
,
N Naderi
,
M Parsaee
,
S Taghavi
,
B Ghadrdoost
,
S Jafari
,
M Khoshavi
,
C Rapezzi
,
E Biagini
,
A Corsini
,
C Gagliardi
,
M Graziosi
,
S Longhi
,
A Milandri
,
L Ragni
,
S Palmieri
,
I Olivotto
,
A Arretini
,
G Castelli
,
F Cecchi
,
A Fornaro
,
B Tomberli
,
P Spirito
,
E Devoto
,
P Della Bella
,
G Maccabelli
,
S Sala
,
F Guarracini
,
G Peretto
,
M Russo
,
R Calabro
,
G Pacileo
,
G Limongelli
,
D Masarone
,
V Pazzanese
,
A Rea
,
M Rubino
,
S Tramonte
,
F Valente
,
M Caiazza
,
A Cirillo
,
G del Giorno
,
A Esposito
,
R Gravino
,
T Marrazzo
,
B Trimarco
,
M-A Losi
,
C Di Nardo
,
A Giamundo
,
F Musella
,
F Pacelli
,
A Scatteia
,
G Canciello
,
A Caforio
,
S Iliceto
,
C Calore
,
L Leoni
,
M Perazzolo Marra
,
I Rigato
,
G Tarantini
,
A Schiavo
,
M Testolina
,
Eloisa Arbustini
,
A Di Toro
,
L Giuliani
,
A Serio
,
F Fedele
,
A Frustaci
,
M Alfarano
,
C Chimenti
,
F Drago
,
A Baban
,
L Calò
,
C Lanzillo
,
A Martino
,
M Uguccioni
,
E Zachara
,
G Halasz
,
F Re
,
G Sinagra
,
C Carriere
,
M Merlo
,
F Ramani
,
A Kavoliuniene
,
A Krivickiene
,
E Tamuleviciute-Prasciene
,
M Viezelis
,
J Celutkiene
,
L Balkeviciene
,
M Laukyte
,
E Paleviciute
,
Y Pinto
,
A Wilde
,
Folkert Asselbergs
,
A Sammani
,
J van der Heijden
,
L van Laake
,
N de Jonge
,
R Hassink
,
J Kirkels
,
J Ajuluchukwu
,
A Olusegun-Joseph
,
E Ekure
,
K Mizia-Stec
,
M Tendera
,
A Czekaj
,
A Sikora-Puz
,
A Skoczynska
,
M Wybraniec
,
P Rubis
,
E Dziewiecka
,
S Wisniowska-Smialek
,
Zofia Bilinska
,
P Chmielewski
,
B Foss-Nieradko
,
E Michalak
,
M Stepien-Wojno
,
B Mazek
,
L Rocha Lopes
,
A Almeida
,
I Cruz
,
A Gomes
,
A Pereira
,
D Brito
,
H Madeira
,
A Francisco
,
M Menezes
,
O Moldovan
,
T Oliveira Guimaraes
,
D Silva
,
C Ginghina
,
R Jurcut
,
A Mursa
,
B Popescu
,
E Apetrei
,
S Militaru
,
I Mircea Coman
,
A Frigy
,
Z Fogarasi
,
I Kocsis
,
I Szabo
,
L Fehervari
,
I Nikitin
,
E Resnik
,
M Komissarova
,
V Lazarev
,
M Shebzukhova
,
D Ustyuzhanin
,
O Blagova
,
I Alieva
,
V Kulikova
,
Y Lutokhina
,
E Pavlenko
,
N Varionchik
,
A Ristic
,
P Seferovic
,
I Veljic
,
I Zivkovic
,
I Milinkovic
,
A Pavlovic
,
G Radovanovic
,
D Simeunovic
,
M Zdravkovic
,
M Aleksic
,
J Djokic
,
S Hinic
,
S Klasnja
,
K Mircetic
,
L Monserrat
,
X Fernandez
,
D Garcia-Giustiniani
,
J Larrañaga
,
M Ortiz-Genga
,
R Barriales-Villa
,
C Martinez-Veira
,
E Veira
,
A Cequier
,
J Salazar-Mendiguchia
,
N Manito
,
J Gonzalez
,
F Fernández-Avilés
,
C Medrano
,
R Yotti
,
S Cuenca
,
M Espinosa
,
I Mendez
,
E Zatarain
,
R Alvarez
,
P Garcia Pavia
,
A Briceno
,
M Cobo-Marcos
,
F Dominguez
,
E de Teresa Galvan
,
J Pinilla
,
N Abdeselam-Mohamed
,
M Lopez-Garrido
,
L Morcillo Hidalgo
,
M Ortega-Jimenez
,
a Robles Mezcua
,
A Guijarro-Contreras
,
D Gomez-Garcia
,
M Robles-Mezcua
,
J Blanes
,
F Castro
,
C Munoz Esparza
,
M Sabater Molina
,
M Sorli García
,
D Lopez Cuenca
,
Palma de Mallorca
,
T Ripoll-Vera
,
J Alvarez
,
J Nunez
,
Y Gomez
,
P Fernandez
,
E Villacorta
,
C Avila
,
L Bravo
,
E Diaz-Pelaez
,
M Gallego-Delgado
,
L Garcia-Cuenllas
,
B Plata
,
J Lopez-Haldon
,
M Pena Pena
,
E Perez
,
E Zorio
,
M Arnau
,
J Sanz
,
E Marques-Sule
Luis Lopes
- Function : Author
- PersonId : 1181174
- ORCID : 0000-0002-6408-4667
Maria-Angela Losi
- Function : Author
Nabeel Sheikh
- Function : Author
Cécile Laroche
- Function : Author
Philippe Charron
- Function : Author
- PersonId : 766599
- IdHAL : philippe-charron
- ORCID : 0000-0002-1782-1118
- IdRef : 123379458
Juan Gimeno
- Function : Author
Juan Kaski
- Function : Author
Aldo Maggioni
- Function : Author
- PersonId : 768290
- ORCID : 0000-0003-2764-6779
Luigi Tavazzi
- Function : Author
Eloisa Arbustini
- Function : Author
- PersonId : 760654
- ORCID : 0000-0003-2948-7994
Dulce Brito
- Function : Author
Jelena Celutkiene
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Albert Hagege
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Ales Linhart
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Jens Mogensen
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José Manuel Garcia-Pinilla
- Function : Author
Tomas Ripoll-Vera
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Hubert Seggewiss
- Function : Author
Eduardo Villacorta
- Function : Author
Alida Caforio
- Function : Author
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Perry Elliott
- Function : Author
Christopher Peter Gale
- Function : Author
Branko Beleslin
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Andrzej Budaj
- Function : Author
Ovidiu Chioncel
- Function : Author
Nikolaos Dagres
- Function : Author
Nicolas Danchin
- Function : Author
David Erlinge
- Function : Author
Jonathan Emberson
- Function : Author
Michael Glikson
- Function : Author
Alastair Gray
- Function : Author
Meral Kayikcioglu
- Function : Author
Aldo Maggioni
- Function : Author
Klaudia Vivien Nagy
- Function : Author
Aleksandr Nedoshivin
- Function : Author
Anna-Sonia Petronio
- Function : Author
Jolien Roo Hesselink
- Function : Author
Lars Wallentin
- Function : Author
Uwe Zeymer
- Function : Author
Alida Caforio
- Function : Author
Juan Ramon Gimeno Blanes
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Philippe Charron
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Perry Elliott
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Juan Pablo Kaski
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Aldo Maggioni
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Luigi Tavazzi
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Michal Tendera
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S Komissarova
- Function : Author
N Chakova
- Function : Author
S Niyazova
- Function : Author
A Linhart
- Function : Author
P Kuchynka
- Function : Author
T Palecek
- Function : Author
J Podzimkova
- Function : Author
M Fikrle
- Function : Author
E Nemecek
- Function : Author
H Bundgaard
- Function : Author
J Tfelt-Hansen
- Function : Author
J Theilade
- Function : Author
J Thune
- Function : Author
A Axelsson
- Function : Author
J Mogensen
- Function : Author
F Henriksen
- Function : Author
T Hey
- Function : Author
S Nielsen
- Function : Author
L Videbaek
- Function : Author
S Andreasen
- Function : Author
H Arnsted
- Function : Author
A Saad
- Function : Author
M Ali
- Function : Author
J Lommi
- Function : Author
T Helio
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M Nieminen
- Function : Author
Olivier Dubourg
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N Mansencal
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M Arslan
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V Siam Tsieu
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T Damy
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A Guellich
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S Guendouz
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C Tissot
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A Lamine
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S Rappeneau
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A Hagege
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M Desnos
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A Bachet
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M Hamzaoui
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Philippe Charron
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Richard Isnard
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L Legrand
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C Maupain
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E Gandjbakhch
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M Kerneis
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J-F Pruny
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A Bauer
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B Pfeiffer
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Stephan Felix
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Marcus Dörr
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S Kaczmarek
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Kristin Lehnert
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A-L Pedersen
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D Beug
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M Bruder
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M Böhm
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I Kindermann
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Y Linicus
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C Werner
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B Neurath
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M Schild-Ungerbuehler
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H Seggewiss
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B Pfeiffer
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A Neugebauer
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P Mckeown
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A Muir
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J Mcosker
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T Jardine
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G Divine
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P Elliott
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M Lorenzini
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O Watkinson
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E Wicks
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H Iqbal
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S Mohiddin
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C O'Mahony
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N Sekri
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G Carr-White
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T Bueser
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R Rajani
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L Clack
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J Damm
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S Jones
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R Sanchez-Vidal
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M Smith
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T Walters
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K Wilson
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S Rosmini
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A Anastasakis
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K Ritsatos
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V Vlagkouli
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T Forster
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R Sepp
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J Borbas
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V Nagy
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A Tringer
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K Kakonyi
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L Szabo
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M Maleki
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F Noohi Bezanjani
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A Amin
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N Naderi
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M Parsaee
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S Taghavi
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B Ghadrdoost
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S Jafari
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M Khoshavi
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C Rapezzi
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E Biagini
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A Corsini
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C Gagliardi
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M Graziosi
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S Longhi
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A Milandri
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L Ragni
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S Palmieri
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I Olivotto
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A Arretini
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G Castelli
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F Cecchi
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A Fornaro
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B Tomberli
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P Spirito
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E Devoto
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P Della Bella
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G Maccabelli
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S Sala
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F Guarracini
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G Peretto
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M Russo
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R Calabro
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G Pacileo
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G Limongelli
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D Masarone
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V Pazzanese
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A Rea
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M Rubino
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S Tramonte
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F Valente
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M Caiazza
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A Cirillo
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G del Giorno
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A Esposito
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R Gravino
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T Marrazzo
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B Trimarco
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M-A Losi
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C Di Nardo
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A Giamundo
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F Musella
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F Pacelli
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A Scatteia
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G Canciello
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A Caforio
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S Iliceto
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C Calore
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L Leoni
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M Perazzolo Marra
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I Rigato
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G Tarantini
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A Schiavo
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M Testolina
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Eloisa Arbustini
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A Di Toro
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L Giuliani
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A Serio
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A Frustaci
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M Alfarano
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C Chimenti
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F Drago
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A Baban
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L Calò
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C Lanzillo
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A Martino
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M Uguccioni
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E Zachara
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G Halasz
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F Re
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G Sinagra
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C Carriere
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M Merlo
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F Ramani
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A Kavoliuniene
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A Krivickiene
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E Tamuleviciute-Prasciene
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M Viezelis
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J Celutkiene
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L Balkeviciene
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M Laukyte
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E Paleviciute
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Y Pinto
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A Wilde
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Folkert Asselbergs
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A Sammani
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J van der Heijden
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L van Laake
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N de Jonge
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R Hassink
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J Kirkels
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J Ajuluchukwu
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A Olusegun-Joseph
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E Ekure
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K Mizia-Stec
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M Tendera
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A Czekaj
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A Sikora-Puz
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A Skoczynska
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M Wybraniec
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P Rubis
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E Dziewiecka
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S Wisniowska-Smialek
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Zofia Bilinska
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P Chmielewski
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B Foss-Nieradko
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E Michalak
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M Stepien-Wojno
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B Mazek
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L Rocha Lopes
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A Almeida
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I Cruz
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A Gomes
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A Pereira
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D Brito
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H Madeira
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A Francisco
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M Menezes
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O Moldovan
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T Oliveira Guimaraes
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D Silva
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C Ginghina
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R Jurcut
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A Mursa
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B Popescu
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E Apetrei
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S Militaru
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I Mircea Coman
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A Frigy
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Z Fogarasi
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I Kocsis
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I Szabo
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L Fehervari
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I Nikitin
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E Resnik
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M Komissarova
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V Lazarev
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M Shebzukhova
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D Ustyuzhanin
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O Blagova
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I Alieva
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V Kulikova
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Y Lutokhina
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E Pavlenko
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N Varionchik
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A Ristic
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P Seferovic
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I Veljic
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I Zivkovic
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I Milinkovic
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A Pavlovic
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G Radovanovic
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D Simeunovic
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M Zdravkovic
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M Aleksic
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J Djokic
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S Hinic
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S Klasnja
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K Mircetic
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L Monserrat
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X Fernandez
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D Garcia-Giustiniani
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J Larrañaga
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M Ortiz-Genga
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R Barriales-Villa
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C Martinez-Veira
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E Veira
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A Cequier
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J Salazar-Mendiguchia
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N Manito
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J Gonzalez
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F Fernández-Avilés
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C Medrano
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R Yotti
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S Cuenca
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M Espinosa
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I Mendez
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E Zatarain
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R Alvarez
- Function : Author
P Garcia Pavia
- Function : Author
A Briceno
- Function : Author
M Cobo-Marcos
- Function : Author
F Dominguez
- Function : Author
E de Teresa Galvan
- Function : Author
J Pinilla
- Function : Author
N Abdeselam-Mohamed
- Function : Author
M Lopez-Garrido
- Function : Author
L Morcillo Hidalgo
- Function : Author
M Ortega-Jimenez
- Function : Author
a Robles Mezcua
- Function : Author
A Guijarro-Contreras
- Function : Author
D Gomez-Garcia
- Function : Author
M Robles-Mezcua
- Function : Author
J Blanes
- Function : Author
F Castro
- Function : Author
C Munoz Esparza
- Function : Author
M Sabater Molina
- Function : Author
M Sorli García
- Function : Author
D Lopez Cuenca
- Function : Author
Palma de Mallorca
- Function : Author
T Ripoll-Vera
- Function : Author
J Alvarez
- Function : Author
J Nunez
- Function : Author
Y Gomez
- Function : Author
P Fernandez
- Function : Author
E Villacorta
- Function : Author
C Avila
- Function : Author
L Bravo
- Function : Author
E Diaz-Pelaez
- Function : Author
M Gallego-Delgado
- Function : Author
L Garcia-Cuenllas
- Function : Author
B Plata
- Function : Author
J Lopez-Haldon
- Function : Author
M Pena Pena
- Function : Author
E Perez
- Function : Author
E Zorio
- Function : Author
M Arnau
- Function : Author
J Sanz
- Function : Author
E Marques-Sule
- Function : Author
Abstract
Abstract Aims The interaction between common cardiovascular risk factors (CVRF) and hypertrophic cardiomyopathy (HCM) is poorly studied. We sought to explore the relation between CVRF and the clinical characteristics of patients with HCM enrolled in the EURObservational Research Programme (EORP) Cardiomyopathy registry. Methods and results 1739 patients with HCM were studied. The relation between hypertension (HT), diabetes (DM), body mass index (BMI), and clinical traits was analysed. Analyses were stratified according to the presence or absence of a pathogenic variant in a sarcomere gene. The prevalence of HT, DM, and obesity (Ob) was 37, 10, and 21%, respectively. HT, DM, and Ob were associated with older age (P<0.001), less family history of HCM (HT and DM P<0.001), higher New York Heart Association (NYHA) class (P<0.001), atrial fibrillation (HT and DM P<0.001; Ob p = 0.03) and LV (left ventricular) diastolic dysfunction (HT and Ob P<0.001; DM P = 0.003). Stroke was more frequent in HT (P<0.001) and mutation-positive patients with DM (P = 0.02). HT and Ob were associated with higher provocable LV outflow tract gradients (HT P<0.001, Ob P = 0.036). LV hypertrophy was more severe in Ob (P = 0.018). HT and Ob were independently associated with NYHA class (OR 1.419, P = 0.017 and OR 1.584, P = 0.004, respectively). Other associations, including a higher proportion of females in HT and of systolic dysfunction in HT and Ob, were observed only in mutation-positive patients. Conclusion Common CVRF are associated with a more severe HCM phenotype, suggesting a proactive management of CVRF should be promoted. An interaction between genotype and CVRF was observed for some traits.