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Article Dans Une Revue Science Année : 2020

Dendritic cell–derived hepcidin sequesters iron from the microbiota to promote mucosal healing

Nicholas Bessman
Jacques Mathieu
  • Fonction : Auteur
Cyril Renassia
  • Fonction : Auteur
Lei Zhou
  • Fonction : Auteur
Thomas Fung
Keith Fernandez
Christine Austin
Jesper Moeller
Sara Zumerle
Sabine Louis
  • Fonction : Auteur
Sophie Vaulont
  • Fonction : Auteur
Nadim Ajami
Harry Sokol
Gregory Putzel
  • Fonction : Auteur
Tara Arvedson
Robbyn Sockolow
Samira Lakhal-Littleton
Suzanne Cloonan
Manish Arora
  • Fonction : Auteur
Carole Peyssonnaux
Gregory Sonnenberg

Résumé

Ironing out the details of mucosal healing Anemia is a frequent complication of disorders such as inflammatory bowel disease, occurring in part as a result of increased bleeding into the intestine. Bessman et al. show that the peptide hormone hepcidin, which regulates systemic iron homeostasis, is required for intestinal repair in a mouse model of inflammatory bowel disease (see the Perspective by Rescigno). This effect was independent of hepatocyte-produced hepcidin and systemic iron levels. Instead, production of hepcidin by conventional dendritic cells was necessary and sufficient to promote local iron sequestration by macrophages, which in turn modulated the makeup of the gut microbiota to one with a more beneficial distribution of species. Science , this issue p. 186 ; see also p. 129

Dates et versions

hal-03998728 , version 1 (21-02-2023)

Identifiants

Citer

Nicholas Bessman, Jacques Mathieu, Cyril Renassia, Lei Zhou, Thomas Fung, et al.. Dendritic cell–derived hepcidin sequesters iron from the microbiota to promote mucosal healing. Science, 2020, 368 (6487), pp.186-189. ⟨10.1126/science.aau6481⟩. ⟨hal-03998728⟩
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