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Article Dans Une Revue Biosensors Année : 2022

Selective Antibody-Free Sensing Membranes for Picogram Tetracycline Detection

Résumé

As an antibody-free sensing membrane for the detection of the antibiotic tetracycline (TC), a liquid PVC membrane doped with the ion-pair tetracycline/θ-shaped anion [3,3-Co(1,2-C 2 B 9 H 11) 2 ] − ([o-COSAN] −) was formulated and deposited on a SWCNT modified gold microelectrode. The chosen transduction technique was electrochemical impedance spectroscopy (EIS). The PVC membrane was composed of: the tetracycline/[o-COSAN] − ion-pair, a plasticizer. A detection limit of 0.3 pg/L was obtained with this membrane, using bis(2-ethylhexyl) sebacate as a plasticizer. The sensitivity of detection of tetracycline was five times higher than that of oxytetracycline and of terramycin, and 22 times higher than that of demeclocycline. A shelf-life of the prepared sensor was more than six months and was used for detection in spiked honey samples. These results open the way to having continuous monitoring sensors with a high detection capacity, are easy to clean, avoid the use of antibodies, and produce a direct measurement.
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Dates et versions

hal-03997564 , version 1 (20-02-2023)

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Hamdi Ben Halima, Abdoullatif Baraket, Clara Vinas, Nadia Zine, Joan Bausells, et al.. Selective Antibody-Free Sensing Membranes for Picogram Tetracycline Detection. Biosensors, 2022, 13 (1), pp.71. ⟨10.3390/bios13010071⟩. ⟨hal-03997564⟩
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