In situ isobaric lipid mapping by MALDI-ion mobility separation-mass spectrometry imaging - Archive ouverte HAL
Poster De Conférence Année : 2020

In situ isobaric lipid mapping by MALDI-ion mobility separation-mass spectrometry imaging

Janina Oetjen
Arnaud Chaumot

Résumé

Lipids are essential components which play critical structural, energy storage and signaling roles in living organisms. MALDI mass spectrometry imaging (MSI) has been widely employed for lipid mapping in biological and biomedical studies to reveal the 2-dimension or 3-dimension localization of important lipid species. However, due to the highly diverse lipid structures, one major challenge in MSI analysis is the separation of isomeric and isobaric lipid species sharing the same nominal m/z value. Here we applied the recently developed timsTOF fleX MALDI MSI platform which incorporates trapped ion mobility spectrometry (TIMS) to perform for the first time in situ mapping and identification of isobaric and isomeric lipids in the freshwater crustacean Gammarus fossarum.

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Dates et versions

hal-03996540 , version 1 (20-02-2023)

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  • HAL Id : hal-03996540 , version 1

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Tingting Fu, Janina Oetjen, Manuel Chapelle, Alexandre Verdu, Matthias Szesny, et al.. In situ isobaric lipid mapping by MALDI-ion mobility separation-mass spectrometry imaging. 68th Conference on Mass Spectrometry and Allied Topics, May 2020, Online, United States. , 2020. ⟨hal-03996540⟩
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