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Article Dans Une Revue Diabetes & Metabolism Année : 2021

Pregnant type 1 diabetes women with rises in C-peptide display higher levels of regulatory T cells: A pilot study

Résumé

Aim: During pregnancy of type 1 diabetes (T1D) women, a C peptide rise has been described, which mechanism is unclear. In T1D, a defect of regulatory T cells (Tregs) and its major controlling cytokine, interleukin-2 (IL2), is observed. Methods: Evolution of clinical, immunological (Treg (CD4+CD25hiCD127-/loFoxp3+ measured by flow cytometry and IL2 measured by luminex xMAP technology) and diabetes parameters (insulin dose per day, HbA1C, glycaemia, C peptide) was evaluated in 13 T1D women during the three trimesters of pregnancy and post-partum (PP, within 6 months) in a monocentric pilot study. Immunological parameters were compared with those of a healthy pregnant cohort (QuTe). Results: An improvement of beta cell function (C peptide rise and/or a decrease of insulin dose-adjusted A1c index that estimate individual exogenous insulin need) was observed in seven women (group 1) whereas the six others (group 2) did not display any positive response to pregnancy. A higher level of Tregs and IL2 was observed in group 1 compared to group 2 during pregnancy and at PP for Tregs level. However, compared to the healthy cohort, T1D women displayed a Treg deficiency CONCLUSION: This pilot study highlights that higher level of Tregs and IL2 seem to allow improvement of endogenous insulin secretion of T1D women during pregnancy.
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hal-03992390 , version 1 (24-02-2023)

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Citer

C. Amouyal, D. Klatzmann, E. Tibi, J.-E. Salem, M. Halbron, et al.. Pregnant type 1 diabetes women with rises in C-peptide display higher levels of regulatory T cells: A pilot study. Diabetes & Metabolism, 2021, 47 (3), pp.101188. ⟨10.1016/j.diabet.2020.04.005⟩. ⟨hal-03992390⟩
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