<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03990636</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-24T22:41:55+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Catalysis before Enzymes: Thiol-Rich Peptides as Molecular Diversity Providers on the Early Earth</title>
            <author role="aut">
              <persName>
                <forename type="first">Ibrahim</forename>
                <surname>Shalayel</surname>
              </persName>
              <email type="md5">cb470bae9cc5cbdd6347b50f9475ca42</email>
              <email type="domain">grenoble-inp.fr</email>
              <idno type="idhal" notation="string">ibrahim-shalayel</idno>
              <idno type="idhal" notation="numeric">170115</idno>
              <idno type="halauthorid" notation="string">37989-170115</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9368-3565</idno>
              <affiliation ref="#struct-1043059"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Naoual</forename>
                <surname>Leqraa</surname>
              </persName>
              <idno type="halauthorid">2022840-0</idno>
              <affiliation ref="#struct-1043098"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Veronique</forename>
                <surname>Blandin</surname>
              </persName>
              <email type="md5">b951779dab1e289db298e07fb011df1a</email>
              <email type="domain">univ-grenoble-alpes.fr</email>
              <idno type="idhal" notation="string">veronique-blandin</idno>
              <idno type="idhal" notation="numeric">182489</idno>
              <idno type="halauthorid" notation="string">2727167-182489</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4516-428X</idno>
              <affiliation ref="#struct-1043098"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yannick</forename>
                <surname>Vallée</surname>
              </persName>
              <email type="md5">5cabf4f597c677ab660b13ecae0480fe</email>
              <email type="domain">univ-grenoble-alpes.fr</email>
              <idno type="idhal" notation="string">vallee-yannick</idno>
              <idno type="idhal" notation="numeric">182491</idno>
              <idno type="halauthorid" notation="string">4186-182491</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8412-8989</idno>
              <idno type="IDREF">https://www.idref.fr/070021694</idno>
              <affiliation ref="#struct-1043098"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Veronique</forename>
                <surname>Blandin</surname>
              </persName>
              <email type="md5">b951779dab1e289db298e07fb011df1a</email>
              <email type="domain">univ-grenoble-alpes.fr</email>
            </editor>
            <funder ref="#projanr-50259"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2025-01-23 15:17:49</date>
              <date type="whenModified">2025-09-27 20:05:02</date>
              <date type="whenReleased">2025-01-28 17:35:42</date>
              <date type="whenProduced">2023-02</date>
              <date type="whenEndEmbargoed">2025-01-23</date>
              <ref type="file" target="https://hal.science/hal-03990636v1/document">
                <date notBefore="2025-01-23"/>
              </ref>
              <ref type="file" subtype="publisherPaid" n="1" target="https://hal.science/hal-03990636v1/file/diversity-15-00256.pdf" id="file-4908661-4262366">
                <date notBefore="2025-01-23"/>
              </ref>
              <ref type="externalLink" target="https://www.mdpi.com/1424-2818/15/2/256/pdf?version=1676182412"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="35906">
                <persName>
                  <forename>Veronique</forename>
                  <surname>Blandin</surname>
                </persName>
                <email type="md5">b951779dab1e289db298e07fb011df1a</email>
                <email type="domain">univ-grenoble-alpes.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03990636</idno>
            <idno type="halUri">https://hal.science/hal-03990636</idno>
            <idno type="halBibtex">shalayel:hal-03990636</idno>
            <idno type="halRefHtml">&lt;i&gt;Diversity&lt;/i&gt;, 2023, 15 (2), pp.256. &lt;a target="_blank" href="https://dx.doi.org/10.3390/d15020256"&gt;&amp;#x27E8;10.3390/d15020256&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Diversity, 2023, 15 (2), pp.256. &amp;#x27E8;10.3390/d15020256&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by/4.0/">CC BY 4.0 - Attribution<ref corresp="#file-4908661-4262366"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="IMAG">IMAG</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="INPG">Institut polytechnique de Grenoble</idno>
            <idno type="stamp" n="TIMC-IMAG">TIMC</idno>
            <idno type="stamp" n="TIMC-IMAG-SYNABI" corresp="TIMC-IMAG">SyNaBi : Systèmes Nanobiotechnologiques et Biomimétiques</idno>
            <idno type="stamp" n="DCM" corresp="CNRS">Département de Chimie Moléculaire</idno>
            <idno type="stamp" n="INC-CNRS">Institut de Chimie du CNRS</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="UGA-EPE">Université Grenoble Alpes [2020-*]</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="LABEX_ARCANE">Labex Arcane</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Catalysis before Enzymes: Thiol-Rich Peptides as Molecular Diversity Providers on the Early Earth</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Ibrahim</forename>
                    <surname>Shalayel</surname>
                  </persName>
                  <email type="md5">cb470bae9cc5cbdd6347b50f9475ca42</email>
                  <email type="domain">grenoble-inp.fr</email>
                  <idno type="idhal" notation="string">ibrahim-shalayel</idno>
                  <idno type="idhal" notation="numeric">170115</idno>
                  <idno type="halauthorid" notation="string">37989-170115</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9368-3565</idno>
                  <affiliation ref="#struct-1043059"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Naoual</forename>
                    <surname>Leqraa</surname>
                  </persName>
                  <idno type="halauthorid">2022840-0</idno>
                  <affiliation ref="#struct-1043098"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Veronique</forename>
                    <surname>Blandin</surname>
                  </persName>
                  <email type="md5">b951779dab1e289db298e07fb011df1a</email>
                  <email type="domain">univ-grenoble-alpes.fr</email>
                  <idno type="idhal" notation="string">veronique-blandin</idno>
                  <idno type="idhal" notation="numeric">182489</idno>
                  <idno type="halauthorid" notation="string">2727167-182489</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4516-428X</idno>
                  <affiliation ref="#struct-1043098"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yannick</forename>
                    <surname>Vallée</surname>
                  </persName>
                  <email type="md5">5cabf4f597c677ab660b13ecae0480fe</email>
                  <email type="domain">univ-grenoble-alpes.fr</email>
                  <idno type="idhal" notation="string">vallee-yannick</idno>
                  <idno type="idhal" notation="numeric">182491</idno>
                  <idno type="halauthorid" notation="string">4186-182491</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8412-8989</idno>
                  <idno type="IDREF">https://www.idref.fr/070021694</idno>
                  <affiliation ref="#struct-1043098"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">101132</idno>
                <idno type="issn">1424-2818</idno>
                <title level="j">Diversity</title>
                <imprint>
                  <publisher>MDPI</publisher>
                  <biblScope unit="volume">15</biblScope>
                  <biblScope unit="issue">2</biblScope>
                  <biblScope unit="pp">256</biblScope>
                  <date type="datePub">2023-02</date>
                </imprint>
              </monogr>
              <idno type="doi">10.3390/d15020256</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Thioesters</term>
                <term xml:lang="en">Cysteine</term>
                <term xml:lang="en">Prebiotic catalysis</term>
                <term xml:lang="en">Origin of life</term>
                <term xml:lang="en">Evolution of enzymes</term>
              </keywords>
              <classCode scheme="halDomain" n="chim">Chemical Sciences</classCode>
              <classCode scheme="halDomain" n="sdu">Sciences of the Universe [physics]</classCode>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>The multiplicity of simple molecules available on the primitive Earth probably made possible the development of extremely diverse prebiotic chemistry. The importance of thiols is widely recognized in the community studying the origin of life. De Duve’s “thioester world” has been considered a major contribution in this regard, where thioester bonds have high energies and thus can contribute to several chemical reactions. Herein, we propose specific models of thiols that exhibit unique activities toward several chemical reactions. Thanks to aminothiol and aminonitrile behaviors, we were able to obtain thiol-rich peptides with interesting catalytic activities leading to the formation of structurally diverse molecules. In a broader context, such chemistry could be introduced into systems chemistry scenarios in which it would be associated with the chemistry of nucleic acids or their precursors, as well as that of fatty acids.</p>
            </abstract>
            <particDesc>
              <org type="consortium">Labex Arcane</org>
            </particDesc>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="researchteam" xml:id="struct-1043059" status="VALID">
          <orgName>Systèmes Nanobiotechnologiques et Biomimétiques</orgName>
          <orgName type="acronym">TIMC-SyNaBi</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <addrLine>Pavillon Taillefer, Rond-point de la Croix de Vie, 38700 La Tronche</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.timc.fr/synabi</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1043049" type="direct"/>
            <relation active="#struct-301767" type="indirect"/>
            <relation name="UMR5525" active="#struct-441569" type="indirect"/>
            <relation active="#struct-1042703" type="indirect"/>
            <relation active="#struct-1043329" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1043098" status="VALID">
          <idno type="IdRef">184748356</idno>
          <idno type="ISNI">0000 0004 0384 0515</idno>
          <idno type="RNSR">200711915A</idno>
          <idno type="ROR">https://ror.org/010rs2a38</idno>
          <orgName>Département de Chimie Moléculaire</orgName>
          <orgName type="acronym">DCM</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>301, rue de la Chimie 38041 GRENOBLE CEDEX 9570, rue de la Chimie 38041 GRENOBLE CEDEX 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://dcm.univ-grenoble-alpes.fr/dcm</ref>
          </desc>
          <listRelation>
            <relation active="#struct-341038" type="direct"/>
            <relation name="UMR5250" active="#struct-441569" type="direct"/>
            <relation active="#struct-1042703" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1043049" status="VALID">
          <idno type="IdRef">14728936X</idno>
          <idno type="ISNI">0000 0004 4687 1979</idno>
          <idno type="RNSR">199511969L</idno>
          <idno type="ROR">https://ror.org/03985kf35</idno>
          <orgName>Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525</orgName>
          <orgName type="acronym">TIMC</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.timc.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301767" type="direct"/>
            <relation name="UMR5525" active="#struct-441569" type="direct"/>
            <relation active="#struct-1042703" type="direct"/>
            <relation active="#struct-1043329" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-301767" status="VALID">
          <idno type="ROR">https://ror.org/01c7wz417</idno>
          <orgName>VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement</orgName>
          <orgName type="acronym">VAS</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Lyon, VetAgro Sup, 69280 Marcy l'Etoile (campus vétérinaire); Université de Clermont, VetAgro Sup, 63370 Lempdes (campus agronomique)</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.vetagro-sup.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-1042703" status="VALID">
          <idno type="IdRef">240648315</idno>
          <idno type="ROR">https://ror.org/02rx3b187</idno>
          <orgName>Université Grenoble Alpes</orgName>
          <orgName type="acronym">UGA</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Adresse CS 40700 - 38058 Grenoble cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-grenoble-alpes.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1043329" status="VALID">
          <idno type="IdRef">026388804</idno>
          <idno type="ROR">https://ror.org/05sbt2524</idno>
          <orgName>Institut polytechnique de Grenoble - Grenoble Institute of Technology</orgName>
          <orgName type="acronym">Grenoble INP</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>46 avenue Félix Viallet 38031 Grenoble Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.grenoble-inp.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1042703" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-341038" status="VALID">
          <idno type="IdRef">232435103</idno>
          <idno type="ISNI">000000010626358X</idno>
          <idno type="ROR">https://ror.org/02cte4b68</idno>
          <orgName>Institut de Chimie - CNRS Chimie</orgName>
          <orgName type="acronym">INC-CNRS</orgName>
          <date type="start">2009-10-01</date>
          <desc>
            <address>
              <addrLine>CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE3 rue Michel-Ange75794 PARIS CEDEX 16 - France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cnrs.fr/inc</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-50259" status="VALID">
          <idno type="anr">ANR-17-EURE-0003</idno>
          <orgName>CBH-EUR-GS</orgName>
          <desc>CBH-EUR-GS</desc>
          <date type="start">2017</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>