The estimation of a biological profile in biological anthropology is a central point inthe study of human remains. To specify this profile, the observation of variations, and patholo-gies on the skeleton is a tool that makes an individual unique. In this research, the focuswas on the distal part of the humerus. Through the study of five individuals from an osteo-archaeological collection, conformational anomalies of the medial epicondyle of the humeruswere highlighted. The aim is to describe them and to propose an etiology of appearance. Forthis purpose, observation of the rest of the skeleton was carried out, in order to search forthe presence of other variations, in particular anomalies of fusion of secondary ossificationcenters. Overall, a non-fusion of the medial epicondyle of the humerus, two fused medialmicro-epicondyles and two supplementary fusions were observed. These are very rare anoma-lies, with an estimated prevalence of 0.7%. Conformational abnormalities of this area can leadto pain. Therefore, medical imaging for diagnostic purposes may be available: useful data forantemortem documentation in case of a disturbing disappearance. Following the study of theentire skeleton, a common etiology for these different conformations cannot be proposed. How-ever, two categories of etiologies can be proposed: a congenital anomaly and a developmentalanomaly with an environmental influence (mechanical or deficiency). The new knowledge ofthis area will enrich the use of individualization factors, especially in the context of forensicanthropology.