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Journal Articles Nephrology Dialysis Transplantation Year : 2021

The spectrum of kidney biopsies in hospitalized patients with COVID-19, acute kidney injury and/or proteinuria

Sophie Ferlicot
  • Function : Author
François Gaillard
Julie Oniszczuk
  • Function : Author
Olivia May
  • Function : Author
Anne Grünenwald
  • Function : Author
Aurélie Sannier
  • Function : Author
Anissa Moktefi
Ophélie Le Monnier
  • Function : Author
Camille Petit-Hoang
  • Function : Author
Nadine Maroun
  • Function : Author
Albane Brodin-Sartorius
  • Function : Author
Arthur Michon
  • Function : Author
Hélène Dobosziewicz
  • Function : Author
Fabrizio Andreelli
  • Function : Author
Matthieu Guillet
  • Function : Author
Hassane Izzedine
  • Function : Author
Christian Richard
  • Function : Author
Manon Dekeyser
  • Function : Author
Romain Arrestier
  • Function : Author
Thomas Stehlé
  • Function : Author
Edouard Lefèvre
  • Function : Author
Christophe Legendre
  • Function : Author
Charlotte Mussini
  • Function : Author
Marie-Christine Verpont
  • Function : Author
Nicolas Pallet
  • Function : Author
Zahir Amoura
  • Function : Author
Renaud Snanoudj
  • Function : Author
Isabelle Brocheriou-Spelle
  • Function : Author
Hélène François
  • Function : Author
Xavier Belenfant
  • Function : Author
Eric Daugas
  • Function : Author
Vincent Audard
  • Function : Author
David Buob
  • Function : Author
Mohamad Zaidan
  • Function : Author

Abstract

Abstract Background The coronavirus disease 2019 (COVID-19) may be associated with kidney injury, which may impact patient's prognosis. Methods We report a multicentric retrospective case series of patients with COVID-19 who developed acute kidney injury (AKI) and/or proteinuria and underwent a kidney biopsy in Paris and its metropolitan area. Results Forty-seven patients (80.9% men) with COVID-19 who underwent a kidney biopsy between 8 March and 19 May 2020 were included. The median age was 63 years (interquartile range 52–69). Comorbidities included hypertension (66.0%), diabetes mellitus (27.7%), obesity (27.7%), history of chronic kidney disease (25.5%), cardiac diseases (38.6%) and respiratory diseases (27.3%). Initial symptoms were fever (85.1%), cough (63.8%), shortness of breath (55.3%) and diarrhoea (23.4%). Almost all patients developed AKI (97.9%) and 63.8% required renal replacement therapy. Kidney biopsy showed two main histopathological patterns, including acute tubular injury in 20 (42.6%) patients, and glomerular injury consisting of collapsing glomerulopathy (CG) and focal segmental glomerulosclerosis in 17 (36.2%) patients. Two (4.3%) patients had acute vascular nephropathy, while 8 (17%) had an alternative diagnosis most likely unrelated to COVID-19. Acute tubular injury occurred almost invariably in the setting of severe forms of COVID-19, whereas patients with glomerular injury had various profiles of COVID-19 severity and CG was only observed in patients harbouring a combination of APOL1 risk variants. At the last follow-up, 16 of the 30 patients who initially required dialysis were still on dialysis, and 9 had died. Conclusions This study describes the spectrum of kidney lesions in patients with COVID-19. While acute tubular injury is correlated with COVID-19 severity, the pattern of glomerular injury is intimately associated with the expression of APOL1 risk variants.

Dates and versions

hal-03983339 , version 1 (10-02-2023)

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Sophie Ferlicot, Matthieu Jamme, François Gaillard, Julie Oniszczuk, Aymeric Couturier, et al.. The spectrum of kidney biopsies in hospitalized patients with COVID-19, acute kidney injury and/or proteinuria. Nephrology Dialysis Transplantation, 2021, 36 (7), pp.1253-1262. ⟨10.1093/ndt/gfab042⟩. ⟨hal-03983339⟩
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