Live stimulated Raman histology for the near-instant assessment of central nervous system samples’ - Archive ouverte HAL
Communication Dans Un Congrès Année : 2023

Live stimulated Raman histology for the near-instant assessment of central nervous system samples’

Hervé Rigneault
Barbara Sarri
  • Fonction : Auteur
  • PersonId : 983869
Sandro Heuke
  • Fonction : Auteur
  • PersonId : 1088523

Résumé

Diagnostic genomic profiling constitutes one of the major challenges to cure brain tumors. The deployment of such analyses depends on the quality of the surgical specimen sent for histopathological examination and further molecular studies. The aim of our study was to assess the potential added value of Stimulated Raman Histology (SRH) for the assessment of freshly excised central nervous system samples. We showed that SRH enabled a near-instant microscopic examination of various central nervous system samples without any tissue processing such as labelling, freezing nor sectioning. Following SRH imaging, we demonstrated that the samples could be readily recovered and reintroduced into a conventional pathology workflow including immunohistochemistry and genomic profiling to establish a definitive diagnosis.
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Dates et versions

hal-03983248 , version 1 (10-02-2023)

Identifiants

  • HAL Id : hal-03983248 , version 1

Citer

Hervé Rigneault, Barbara Sarri, Sandro Heuke, Romain Appey, S Boissonneau. Live stimulated Raman histology for the near-instant assessment of central nervous system samples’. Photonic West 2023, Jan 2023, San Francisco, United States. ⟨hal-03983248⟩
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