CELL PENETRATING PEPTIDE DECORATED-MAGNETIC POROUS SILICON NANORODS FOR GLIOBLASTOMA IMAGING AND THERAPY - Archive ouverte HAL Accéder directement au contenu
Communication Dans Un Congrès Année : 2022

CELL PENETRATING PEPTIDE DECORATED-MAGNETIC POROUS SILICON NANORODS FOR GLIOBLASTOMA IMAGING AND THERAPY

Résumé

Glioblastoma multiforme (GBM) is the most aggressive type of cancer that begins within the brain. Despite advances in treatment, it remains largely untreatable , in part due to the low permeability of chemotherapeutic drugs to cross the blood-brain barrier (BBB) which significantly compromises their effectiveness. To circumvent the lack of drugs efficiency, we designed multifunctional nanoparticles based on porous silicon nanorods (pSiNRs). A Neurofilament light subunit derived 24 amino acid tubulin binding site peptide called NFL-peptide was reported to preferentially targeted human GBM cells compared to the healthy human cells.1, 2 Motivated by this approach, we investigated the use of magnetic-pSiNRs decorated with the NFL-TBS.40-63 peptide (NFL-peptide) to facilitate the targeting and enhance the internalization into human GBM cells. Additionally, we showed that the uptake of NFL-peptide coated magnetic-pSiNRs was preferential towards human GBM cells.
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Dates et versions

hal-03980738 , version 1 (09-02-2023)

Identifiants

  • HAL Id : hal-03980738 , version 1

Citer

Arnaud Chaix, Audrey Griveau, Thomas Defforge, Virginie Grimal, Brice Le Borgne, et al.. CELL PENETRATING PEPTIDE DECORATED-MAGNETIC POROUS SILICON NANORODS FOR GLIOBLASTOMA IMAGING AND THERAPY. Porous Semiconductors - Science and Technology, Mar 2022, Lido Di Camaiore, Italy. ⟨hal-03980738⟩
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