<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03979823</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-20T22:55:08+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance</title>
            <author role="aut">
              <persName>
                <forename type="first">Diego</forename>
                <surname>Calvisi</surname>
              </persName>
              <idno type="idhal" notation="numeric">1225160</idno>
              <idno type="halauthorid" notation="string">1703032-1225160</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6038-8567</idno>
              <affiliation ref="#struct-303027"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Luke</forename>
                <surname>Boulter</surname>
              </persName>
              <idno type="idhal" notation="numeric">1225161</idno>
              <idno type="halauthorid" notation="string">2129125-1225161</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-7954-6705</idno>
              <affiliation ref="#struct-61277"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Javier</forename>
                <surname>Vaquero</surname>
              </persName>
              <email type="md5">71038bdc767e271beeba9858be89f48b</email>
              <email type="domain">idibell.cat</email>
              <idno type="idhal" notation="numeric">1109265</idno>
              <idno type="halauthorid" notation="string">871121-1109265</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-6020-6962</idno>
              <affiliation ref="#struct-308343"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Anna</forename>
                <surname>Saborowski</surname>
              </persName>
              <idno type="halauthorid">2718828-0</idno>
              <affiliation ref="#struct-505089"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Luca</forename>
                <surname>Fabris</surname>
              </persName>
              <idno type="idhal" notation="numeric">1223849</idno>
              <idno type="halauthorid" notation="string">2129124-1223849</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8538-6317</idno>
              <affiliation ref="#struct-51214"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pedro</forename>
                <surname>Rodrigues</surname>
              </persName>
              <email type="md5">5c78948ddff3bdaf5329df7a290345b6</email>
              <email type="domain">biodonostia.org</email>
              <idno type="idhal" notation="numeric">1225163</idno>
              <idno type="halauthorid" notation="string">653544-1225163</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6193-7436</idno>
              <affiliation ref="#struct-308343"/>
              <affiliation ref="#struct-302177"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Cédric</forename>
                <surname>Coulouarn</surname>
              </persName>
              <idno type="halauthorid">736541-0</idno>
              <affiliation ref="#struct-1090097"/>
              <affiliation ref="#struct-301510"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Rui</forename>
                <surname>Castro</surname>
              </persName>
              <email type="md5">0f904d138a33ad532460cd4aabe36d90</email>
              <email type="domain">ff.ulisboa.pt</email>
              <idno type="idhal" notation="numeric">1225164</idno>
              <idno type="halauthorid" notation="string">1108360-1225164</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-7417-0091</idno>
              <affiliation ref="#struct-1114557"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Oreste</forename>
                <surname>Segatto</surname>
              </persName>
              <idno type="halauthorid">1557645-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Chiara</forename>
                <surname>Raggi</surname>
              </persName>
              <email type="md5">f5bbda9a7370b508ac51fffd8de68786</email>
              <email type="domain">unifi.it</email>
              <idno type="idhal" notation="numeric">1059885</idno>
              <idno type="halauthorid" notation="string">1092549-1059885</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2473-3535</idno>
              <affiliation ref="#struct-148408"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Luc</forename>
                <surname>van der Laan</surname>
              </persName>
              <idno type="idhal" notation="numeric">1225165</idno>
              <idno type="halauthorid" notation="string">2718829-1225165</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0651-5334</idno>
              <affiliation ref="#struct-308157"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Guido</forename>
                <surname>Carpino</surname>
              </persName>
              <idno type="idhal" notation="numeric">1225166</idno>
              <idno type="halauthorid" notation="string">2129120-1225166</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-8570-2519</idno>
              <affiliation ref="#struct-452000"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Benjamin</forename>
                <surname>Goeppert</surname>
              </persName>
              <idno type="idhal" notation="numeric">1225167</idno>
              <idno type="halauthorid" notation="string">2062368-1225167</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4135-9250</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Stephanie</forename>
                <surname>Roessler</surname>
              </persName>
              <idno type="idhal" notation="numeric">1225168</idno>
              <idno type="halauthorid" notation="string">1721390-1225168</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5333-5942</idno>
              <affiliation ref="#struct-336942"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Timothy</forename>
                <surname>Kendall</surname>
              </persName>
              <idno type="idhal" notation="numeric">1225169</idno>
              <idno type="halauthorid" notation="string">2718830-1225169</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4174-2786</idno>
              <affiliation ref="#struct-61277"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Matthias</forename>
                <surname>Evert</surname>
              </persName>
              <idno type="halauthorid">2718831-0</idno>
              <affiliation ref="#struct-303027"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ester</forename>
                <surname>Gonzalez-Sanchez</surname>
              </persName>
              <idno type="idhal" notation="numeric">1225170</idno>
              <idno type="halauthorid" notation="string">871120-1225170</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9636-9624</idno>
              <affiliation ref="#struct-3447"/>
              <affiliation ref="#struct-171924"/>
              <affiliation ref="#struct-301917"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Juan</forename>
                <surname>Valle</surname>
              </persName>
              <idno type="idhal" notation="numeric">803782</idno>
              <idno type="halauthorid" notation="string">2074474-803782</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1999-0863</idno>
              <affiliation ref="#struct-1040226"/>
              <affiliation ref="#struct-121172"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Arndt</forename>
                <surname>Vogel</surname>
              </persName>
              <idno type="idhal" notation="numeric">1225171</idno>
              <idno type="halauthorid" notation="string">2228075-1225171</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0560-5538</idno>
              <affiliation ref="#struct-505089"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">John</forename>
                <surname>Bridgewater</surname>
              </persName>
              <idno type="idhal" notation="numeric">1225172</idno>
              <idno type="halauthorid" notation="string">1214455-1225172</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9186-1604</idno>
              <affiliation ref="#struct-300875"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mitesh</forename>
                <surname>Borad</surname>
              </persName>
              <idno type="halauthorid">2158523-0</idno>
              <affiliation ref="#struct-310910"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Gregory</forename>
                <surname>Gores</surname>
              </persName>
              <idno type="idhal" notation="numeric">1224340</idno>
              <idno type="halauthorid" notation="string">1049506-1224340</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-3151-009X</idno>
              <affiliation ref="#struct-157897"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Lewis</forename>
                <surname>Roberts</surname>
              </persName>
              <idno type="idhal" notation="numeric">1225173</idno>
              <idno type="halauthorid" notation="string">2122814-1225173</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-7885-8574</idno>
              <affiliation ref="#struct-157897"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jose</forename>
                <surname>Marin</surname>
              </persName>
              <idno type="idhal" notation="numeric">1223857</idno>
              <idno type="halauthorid" notation="string">547722-1223857</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-1186-6849</idno>
              <affiliation ref="#struct-308343"/>
              <affiliation ref="#struct-300499"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jesper</forename>
                <surname>Andersen</surname>
              </persName>
              <idno type="idhal" notation="numeric">1174837</idno>
              <idno type="halauthorid" notation="string">614829-1174837</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-1760-5244</idno>
              <affiliation ref="#struct-460939"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Domenico</forename>
                <surname>Alvaro</surname>
              </persName>
              <idno type="halauthorid">1092554-0</idno>
              <affiliation ref="#struct-229915"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Alejandro</forename>
                <surname>Forner</surname>
              </persName>
              <idno type="idhal" notation="numeric">1225174</idno>
              <idno type="halauthorid" notation="string">2129134-1225174</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9014-4950</idno>
              <affiliation ref="#struct-3447"/>
              <affiliation ref="#struct-308343"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jesus</forename>
                <surname>Banales</surname>
              </persName>
              <idno type="idhal" notation="numeric">1225175</idno>
              <idno type="halauthorid" notation="string">1092560-1225175</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5224-2373</idno>
              <affiliation ref="#struct-302177"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Vincenzo</forename>
                <surname>Cardinale</surname>
              </persName>
              <idno type="halauthorid">1092553-0</idno>
              <affiliation ref="#struct-229915"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Rocio</forename>
                <surname>Macias</surname>
              </persName>
              <idno type="idhal" notation="numeric">1225176</idno>
              <idno type="halauthorid" notation="string">2715763-1225176</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4748-0326</idno>
              <affiliation ref="#struct-300499"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Silve</forename>
                <surname>Vicent</surname>
              </persName>
              <idno type="idhal" notation="numeric">821669</idno>
              <idno type="halauthorid" notation="string">2718832-821669</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9457-6881</idno>
              <affiliation ref="#struct-160788"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Xin</forename>
                <surname>Chen</surname>
              </persName>
              <idno type="halauthorid">465003-0</idno>
              <affiliation ref="#struct-190541"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Chiara</forename>
                <surname>Braconi</surname>
              </persName>
              <idno type="halauthorid">2129121-0</idno>
              <affiliation ref="#struct-25887"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Monique</forename>
                <surname>Verstegen</surname>
              </persName>
              <idno type="halauthorid">2718833-0</idno>
              <affiliation ref="#struct-308157"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Laura</forename>
                <surname>Fouassier</surname>
              </persName>
              <email type="md5">3a34082746cf76e2cf8b30e82017bece</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="string">laura-fouassier</idno>
              <idno type="idhal" notation="numeric">968390</idno>
              <idno type="halauthorid" notation="string">871122-968390</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6377-5610</idno>
              <idno type="IDREF">https://www.idref.fr/080920225</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=-rZ1zw0AAAAJ</idno>
              <affiliation ref="#struct-541912"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Lewis</forename>
                <surname>Roberts</surname>
              </persName>
              <idno type="halauthorid">2122814-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Alexander</forename>
                <surname>Scheiter</surname>
              </persName>
              <idno type="halauthorid">2718834-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Florin</forename>
                <surname>Selaru</surname>
              </persName>
              <idno type="halauthorid">2718835-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Katja</forename>
                <surname>Evert</surname>
              </persName>
              <idno type="halauthorid">2572951-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Kirsten</forename>
                <surname>Utpatel</surname>
              </persName>
              <idno type="halauthorid">2718836-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Laura</forename>
                <surname>Broutier</surname>
              </persName>
              <email type="md5">5d78ad8fe9c6c166c3542838652cc355</email>
              <email type="domain">lyon.unicancer.fr</email>
              <idno type="idhal" notation="string">laura-broutier</idno>
              <idno type="idhal" notation="numeric">1331825</idno>
              <idno type="halauthorid" notation="string">650946-1331825</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5163-5573</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Massimiliano</forename>
                <surname>Cadamuro</surname>
              </persName>
              <idno type="halauthorid">2151678-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Meritxell</forename>
                <surname>Huch</surname>
              </persName>
              <idno type="halauthorid">1770579-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Robert</forename>
                <surname>Goldin</surname>
              </persName>
              <idno type="halauthorid">538204-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sergio</forename>
                <surname>Gradilone</surname>
              </persName>
              <idno type="halauthorid">2718837-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yoshimasa</forename>
                <surname>Saito</surname>
              </persName>
              <idno type="halauthorid">2718838-0</idno>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Laura</forename>
                <surname>Fouassier</surname>
              </persName>
              <email type="md5">3a34082746cf76e2cf8b30e82017bece</email>
              <email type="domain">inserm.fr</email>
            </editor>
            <funder>The authors thank the European Network for the Study of Cholangiocarcinoma (ENS-CCA) and the European H2020 COST Action CA18122. The authors also acknowledge the valuable contributions of the external advisory panel. C.C. is supported by Inserm, Université de Rennes 1 and by a grant from the French Ministry of Health and the French National Cancer Institute (PRT-K20-136), CHU Rennes, CLCC Eugène Marquis, Rennes. M.M.A.V. and L.J.W.v.d.L. are supported by Medical Delta Regenerative Medicine 4D (Generating complex tissues with stem cells and printing technology) and TKI-LSH grant EMC-LSH19002. S.R. is supported by the German Research Foundation (DFG, project no. 314905040 and no. 493697503) and by German Cancer Aid (Deutsche Krebshilfe, project no. 70113922). S.V. is supported by Ministerio de Ciencia, Innovación y Universidades, Convocatoria 2019 para incentivar la Incorporación Estable de Doctores (IED2019-001007-I), by FEDER/Ministerio de Ciencia, Innovación y Universidades – Agencia Estatal de Investigación (PID2020‐116344‐RB‐100) and by the Government of Navarra-Health Research Department (58; 2018). J.V. is funded by Ministerio de Ciencia e Innovación, part of Agencia Estatal de Investigación (AEI), through the Retos Investigación grant number PID2019-108651RJ-I00/DOI 10.13039/501100011033. The authors thank CERCA Programme/Generalitat de Catalunya for institutional support. R.I.R.M. and J.J.G.M. are supported by Instituto de Salud Carlos III, Spain (PI20/00189, PI19/00819) co-funded by the European Union. L. Fouassier belongs to a team supported by the Fondation pour la Recherche Médicale (Equipe FRM 2020 no. EQU202003010517) and is supported by Inserm and Sorbonne Université, INCa and ITMO Cancer of Aviesan within the framework of the 2021–2030 Cancer Control Strategy, on funds administered by Inserm.</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2023-07-12 13:25:14</date>
              <date type="whenModified">2026-02-07 05:25:44</date>
              <date type="whenReleased">2023-07-12 13:25:21</date>
              <date type="whenProduced">2023-02-08</date>
              <date type="whenEndEmbargoed">2023-08-08</date>
              <ref type="file" target="https://hal.science/hal-03979823v1/document">
                <date notBefore="2023-08-08"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.science/hal-03979823v1/file/Calvisi%20et%20al%20-%202023%20-%20Criteria%20for%20preclinical%20models%20of%20cholangiocarcinoma%20_59081_2_art_file_529801_rhdbs3.pdf" id="file-4160304-3622697">
                <date notBefore="2023-08-08"/>
              </ref>
              <ref type="annex" n="0" target="https://hal.science/hal-03979823v1/file/Cal_41575_2022_739_MOESM1_ESM.pdf" id="file-4160304-3622698">
                <date notBefore="2023-08-08"/>
              </ref>
              <ref type="externalLink" target="https://www.nature.com/articles/s41575-022-00739-y.pdf"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="163433">
                <persName>
                  <forename>Laura</forename>
                  <surname>Fouassier</surname>
                </persName>
                <email type="md5">3a34082746cf76e2cf8b30e82017bece</email>
                <email type="domain">inserm.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03979823</idno>
            <idno type="halUri">https://hal.science/hal-03979823</idno>
            <idno type="halBibtex">calvisi:hal-03979823</idno>
            <idno type="halRefHtml">&lt;i&gt;Nature reviews. Gastroenterology &amp; hepatology&lt;/i&gt;, 2023, 20 (7), pp.462-480. &lt;a target="_blank" href="https://dx.doi.org/10.1038/s41575-022-00739-y"&gt;&amp;#x27E8;10.1038/s41575-022-00739-y&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Nature reviews. Gastroenterology &amp; hepatology, 2023, 20 (7), pp.462-480. &amp;#x27E8;10.1038/s41575-022-00739-y&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by-nc/4.0/">CC BY-NC 4.0 - Attribution - Non-commercial use<ref corresp="#file-4160304-3622697"/><ref corresp="#file-4160304-3622698"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UNIV-RENNES1">Université de Rennes 1</idno>
            <idno type="stamp" n="UNIV-LYON1">Université Claude Bernard - Lyon I</idno>
            <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno>
            <idno type="stamp" n="FNCLCC" corresp="INSERM">UNICANCER</idno>
            <idno type="stamp" n="MARQUIS" corresp="FNCLCC">Centre Eugène Marquis</idno>
            <idno type="stamp" n="U938" corresp="SORBONNE-UNIVERSITE">Centre de recherche Saint-Antoine - UMR S938</idno>
            <idno type="stamp" n="OSS">Chemistry Oncogenesis Stress Signaling</idno>
            <idno type="stamp" n="UR1-UFR-SVE">UFR SVE Sciences de la vie et de l'environnement</idno>
            <idno type="stamp" n="UR1-HAL">Publications labos UR1 dans HAL-Rennes 1</idno>
            <idno type="stamp" n="UR1-SDV">UR1 - publications SDV</idno>
            <idno type="stamp" n="TEST-UR-CSS">TEST Université de Rennes CSS</idno>
            <idno type="stamp" n="CRCL" corresp="UNIV-LYON1">Centre de recherche en cancérologie de Lyon (UMR INSERM 1052 ; CNRS 5286 ; Centre Léon Bérard)</idno>
            <idno type="stamp" n="UNIV-RENNES">Université de Rennes</idno>
            <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno>
            <idno type="stamp" n="SORBONNE-UNIV" corresp="SORBONNE-UNIVERSITE">Sorbonne Université 01/01/2018</idno>
            <idno type="stamp" n="SU-MEDECINE" corresp="SORBONNE-UNIVERSITE">Faculté de Santé de Sorbonne Université</idno>
            <idno type="stamp" n="UDL">UDL</idno>
            <idno type="stamp" n="SU-TI">Sorbonne Université - Texte Intégral</idno>
            <idno type="stamp" n="UR1-BIO-SA">Pôle UnivRennes - Biologie-Santé</idno>
            <idno type="stamp" n="ALLIANCE-SU"> Alliance Sorbonne Université</idno>
            <idno type="stamp" n="CRCL-EQUIPE-M-CASTETS-J-Y-BLAY" corresp="CRCL">CRCL-Mort cellulaire et cancers pédiatriques</idno>
            <idno type="stamp" n="FRM">Fondation pour la Recherche Médicale</idno>
            <idno type="stamp" n="SUPRA_-SVE6">SVE6 - Maladies humaines</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Diego</forename>
                    <surname>Calvisi</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1225160</idno>
                  <idno type="halauthorid" notation="string">1703032-1225160</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6038-8567</idno>
                  <affiliation ref="#struct-303027"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Luke</forename>
                    <surname>Boulter</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1225161</idno>
                  <idno type="halauthorid" notation="string">2129125-1225161</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-7954-6705</idno>
                  <affiliation ref="#struct-61277"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Javier</forename>
                    <surname>Vaquero</surname>
                  </persName>
                  <email type="md5">71038bdc767e271beeba9858be89f48b</email>
                  <email type="domain">idibell.cat</email>
                  <idno type="idhal" notation="numeric">1109265</idno>
                  <idno type="halauthorid" notation="string">871121-1109265</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-6020-6962</idno>
                  <affiliation ref="#struct-308343"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Anna</forename>
                    <surname>Saborowski</surname>
                  </persName>
                  <idno type="halauthorid">2718828-0</idno>
                  <affiliation ref="#struct-505089"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Luca</forename>
                    <surname>Fabris</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1223849</idno>
                  <idno type="halauthorid" notation="string">2129124-1223849</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8538-6317</idno>
                  <affiliation ref="#struct-51214"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pedro</forename>
                    <surname>Rodrigues</surname>
                  </persName>
                  <email type="md5">5c78948ddff3bdaf5329df7a290345b6</email>
                  <email type="domain">biodonostia.org</email>
                  <idno type="idhal" notation="numeric">1225163</idno>
                  <idno type="halauthorid" notation="string">653544-1225163</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6193-7436</idno>
                  <affiliation ref="#struct-308343"/>
                  <affiliation ref="#struct-302177"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Cédric</forename>
                    <surname>Coulouarn</surname>
                  </persName>
                  <idno type="halauthorid">736541-0</idno>
                  <affiliation ref="#struct-1090097"/>
                  <affiliation ref="#struct-301510"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Rui</forename>
                    <surname>Castro</surname>
                  </persName>
                  <email type="md5">0f904d138a33ad532460cd4aabe36d90</email>
                  <email type="domain">ff.ulisboa.pt</email>
                  <idno type="idhal" notation="numeric">1225164</idno>
                  <idno type="halauthorid" notation="string">1108360-1225164</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-7417-0091</idno>
                  <affiliation ref="#struct-1114557"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Oreste</forename>
                    <surname>Segatto</surname>
                  </persName>
                  <idno type="halauthorid">1557645-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Chiara</forename>
                    <surname>Raggi</surname>
                  </persName>
                  <email type="md5">f5bbda9a7370b508ac51fffd8de68786</email>
                  <email type="domain">unifi.it</email>
                  <idno type="idhal" notation="numeric">1059885</idno>
                  <idno type="halauthorid" notation="string">1092549-1059885</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2473-3535</idno>
                  <affiliation ref="#struct-148408"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Luc</forename>
                    <surname>van der Laan</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1225165</idno>
                  <idno type="halauthorid" notation="string">2718829-1225165</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0651-5334</idno>
                  <affiliation ref="#struct-308157"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Guido</forename>
                    <surname>Carpino</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1225166</idno>
                  <idno type="halauthorid" notation="string">2129120-1225166</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-8570-2519</idno>
                  <affiliation ref="#struct-452000"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Benjamin</forename>
                    <surname>Goeppert</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1225167</idno>
                  <idno type="halauthorid" notation="string">2062368-1225167</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4135-9250</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Stephanie</forename>
                    <surname>Roessler</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1225168</idno>
                  <idno type="halauthorid" notation="string">1721390-1225168</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5333-5942</idno>
                  <affiliation ref="#struct-336942"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Timothy</forename>
                    <surname>Kendall</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1225169</idno>
                  <idno type="halauthorid" notation="string">2718830-1225169</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4174-2786</idno>
                  <affiliation ref="#struct-61277"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Matthias</forename>
                    <surname>Evert</surname>
                  </persName>
                  <idno type="halauthorid">2718831-0</idno>
                  <affiliation ref="#struct-303027"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ester</forename>
                    <surname>Gonzalez-Sanchez</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1225170</idno>
                  <idno type="halauthorid" notation="string">871120-1225170</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9636-9624</idno>
                  <affiliation ref="#struct-3447"/>
                  <affiliation ref="#struct-171924"/>
                  <affiliation ref="#struct-301917"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Juan</forename>
                    <surname>Valle</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">803782</idno>
                  <idno type="halauthorid" notation="string">2074474-803782</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1999-0863</idno>
                  <affiliation ref="#struct-1040226"/>
                  <affiliation ref="#struct-121172"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Arndt</forename>
                    <surname>Vogel</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1225171</idno>
                  <idno type="halauthorid" notation="string">2228075-1225171</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0560-5538</idno>
                  <affiliation ref="#struct-505089"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">John</forename>
                    <surname>Bridgewater</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1225172</idno>
                  <idno type="halauthorid" notation="string">1214455-1225172</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9186-1604</idno>
                  <affiliation ref="#struct-300875"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mitesh</forename>
                    <surname>Borad</surname>
                  </persName>
                  <idno type="halauthorid">2158523-0</idno>
                  <affiliation ref="#struct-310910"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Gregory</forename>
                    <surname>Gores</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1224340</idno>
                  <idno type="halauthorid" notation="string">1049506-1224340</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3151-009X</idno>
                  <affiliation ref="#struct-157897"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Lewis</forename>
                    <surname>Roberts</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1225173</idno>
                  <idno type="halauthorid" notation="string">2122814-1225173</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-7885-8574</idno>
                  <affiliation ref="#struct-157897"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jose</forename>
                    <surname>Marin</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1223857</idno>
                  <idno type="halauthorid" notation="string">547722-1223857</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-1186-6849</idno>
                  <affiliation ref="#struct-308343"/>
                  <affiliation ref="#struct-300499"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jesper</forename>
                    <surname>Andersen</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1174837</idno>
                  <idno type="halauthorid" notation="string">614829-1174837</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-1760-5244</idno>
                  <affiliation ref="#struct-460939"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Domenico</forename>
                    <surname>Alvaro</surname>
                  </persName>
                  <idno type="halauthorid">1092554-0</idno>
                  <affiliation ref="#struct-229915"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Alejandro</forename>
                    <surname>Forner</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1225174</idno>
                  <idno type="halauthorid" notation="string">2129134-1225174</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9014-4950</idno>
                  <affiliation ref="#struct-3447"/>
                  <affiliation ref="#struct-308343"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jesus</forename>
                    <surname>Banales</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1225175</idno>
                  <idno type="halauthorid" notation="string">1092560-1225175</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5224-2373</idno>
                  <affiliation ref="#struct-302177"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Vincenzo</forename>
                    <surname>Cardinale</surname>
                  </persName>
                  <idno type="halauthorid">1092553-0</idno>
                  <affiliation ref="#struct-229915"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Rocio</forename>
                    <surname>Macias</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1225176</idno>
                  <idno type="halauthorid" notation="string">2715763-1225176</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4748-0326</idno>
                  <affiliation ref="#struct-300499"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Silve</forename>
                    <surname>Vicent</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">821669</idno>
                  <idno type="halauthorid" notation="string">2718832-821669</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9457-6881</idno>
                  <affiliation ref="#struct-160788"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Xin</forename>
                    <surname>Chen</surname>
                  </persName>
                  <idno type="halauthorid">465003-0</idno>
                  <affiliation ref="#struct-190541"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Chiara</forename>
                    <surname>Braconi</surname>
                  </persName>
                  <idno type="halauthorid">2129121-0</idno>
                  <affiliation ref="#struct-25887"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Monique</forename>
                    <surname>Verstegen</surname>
                  </persName>
                  <idno type="halauthorid">2718833-0</idno>
                  <affiliation ref="#struct-308157"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Laura</forename>
                    <surname>Fouassier</surname>
                  </persName>
                  <email type="md5">3a34082746cf76e2cf8b30e82017bece</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="string">laura-fouassier</idno>
                  <idno type="idhal" notation="numeric">968390</idno>
                  <idno type="halauthorid" notation="string">871122-968390</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6377-5610</idno>
                  <idno type="IDREF">https://www.idref.fr/080920225</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=-rZ1zw0AAAAJ</idno>
                  <affiliation ref="#struct-541912"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Lewis</forename>
                    <surname>Roberts</surname>
                  </persName>
                  <idno type="halauthorid">2122814-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Alexander</forename>
                    <surname>Scheiter</surname>
                  </persName>
                  <idno type="halauthorid">2718834-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Florin</forename>
                    <surname>Selaru</surname>
                  </persName>
                  <idno type="halauthorid">2718835-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Katja</forename>
                    <surname>Evert</surname>
                  </persName>
                  <idno type="halauthorid">2572951-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Kirsten</forename>
                    <surname>Utpatel</surname>
                  </persName>
                  <idno type="halauthorid">2718836-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Laura</forename>
                    <surname>Broutier</surname>
                  </persName>
                  <email type="md5">5d78ad8fe9c6c166c3542838652cc355</email>
                  <email type="domain">lyon.unicancer.fr</email>
                  <idno type="idhal" notation="string">laura-broutier</idno>
                  <idno type="idhal" notation="numeric">1331825</idno>
                  <idno type="halauthorid" notation="string">650946-1331825</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5163-5573</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Massimiliano</forename>
                    <surname>Cadamuro</surname>
                  </persName>
                  <idno type="halauthorid">2151678-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Meritxell</forename>
                    <surname>Huch</surname>
                  </persName>
                  <idno type="halauthorid">1770579-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Robert</forename>
                    <surname>Goldin</surname>
                  </persName>
                  <idno type="halauthorid">538204-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sergio</forename>
                    <surname>Gradilone</surname>
                  </persName>
                  <idno type="halauthorid">2718837-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yoshimasa</forename>
                    <surname>Saito</surname>
                  </persName>
                  <idno type="halauthorid">2718838-0</idno>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">108813</idno>
                <idno type="issn">1759-5045</idno>
                <idno type="eissn">1759-5053</idno>
                <title level="j">Nature reviews. Gastroenterology &amp; hepatology</title>
                <imprint>
                  <publisher>Nature Publishing Group, 2009-</publisher>
                  <biblScope unit="volume">20</biblScope>
                  <biblScope unit="issue">7</biblScope>
                  <biblScope unit="pp">462–480</biblScope>
                  <date type="datePub">2023-02-08</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1038/s41575-022-00739-y</idno>
              <idno type="pubmed">36755084</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halDomain" n="sdv.can">Life Sciences [q-bio]/Cancer</classCode>
              <classCode scheme="halDomain" n="sdv.mhep.heg">Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Cholangiocarcinoma (CCA) is a rare malignancy that develops at any point along the biliary tree. CCA has a poor prognosis, its clinical management remains challenging, and effective treatments are lacking. Therefore, preclinical research is of pivotal importance and necessary to acquire a deeper understanding of CCA and improve therapeutic outcomes. Preclinical research involves developing and managing complementary experimental models, from in vitro assays using primary cells or cell lines cultured in 2D or 3D to in vivo models with engrafted material, chemically induced CCA or genetically engineered models. All are valuable tools with well-defined advantages and limitations. The choice of a preclinical model is guided by the question(s) to be addressed; ideally, results should be recapitulated in independent approaches. In this Consensus Statement, a task force of 45 experts in CCA molecular and cellular biology and clinicians, including pathologists, from ten countries provides recommendations on the minimal criteria for preclinical models to provide a uniform approach. These recommendations are based on two rounds of questionnaires completed by 35 (first round) and 45 (second round) experts to reach a consensus with 13 statements. An agreement was defined when at least 90% of the participants voting anonymously agreed with a statement. The ultimate goal was to transfer basic laboratory research to the clinics through increased disease understanding and to develop clinical biomarkers and innovative therapies for patients with CCA.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-303027" status="VALID">
          <idno type="ROR">https://ror.org/01eezs655</idno>
          <orgName>Universität Regensburg =  University of Regensburg = Université de Ratisbonne [Allemagne]</orgName>
          <orgName type="acronym">UR</orgName>
          <date type="start">2016-10-17</date>
          <desc>
            <address>
              <addrLine>Universitätsstraße 31, 93053 Regensburg</addrLine>
              <country key="DE"/>
            </address>
            <ref type="url">http://www.uni-regensburg.de</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-61277" status="VALID">
          <idno type="IdRef">02663483X</idno>
          <idno type="ROR">https://ror.org/01nrxwf90</idno>
          <orgName>The University of Edinburgh</orgName>
          <date type="start">1583-01-01</date>
          <desc>
            <address>
              <addrLine>Old College South Bridge Edinburgh EH8 9YL</addrLine>
              <country key="GB"/>
            </address>
            <ref type="url">http://www.ed.ac.uk/home</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-308343" status="VALID">
          <idno type="ROR">https://ror.org/00ca2c886</idno>
          <orgName>Instituto de Salud Carlos III [Madrid]</orgName>
          <orgName type="acronym">ISCIII</orgName>
          <desc>
            <address>
              <addrLine>Carretera de Majadahonda - Pozuelo, 28220 Majadahonda, Madrid, Espagne</addrLine>
              <country key="ES"/>
            </address>
            <ref type="url">http://www.isciii.es/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-505089" status="VALID">
          <orgName>Medizinische Hochschule Hannover = Hannover Medical School</orgName>
          <orgName type="acronym">MHH</orgName>
          <desc>
            <address>
              <addrLine>Carl-Neuberg-Straße 1, 30625 Hannover,</addrLine>
              <country key="DE"/>
            </address>
            <ref type="url">https://www.mh-hannover.de/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-51214" status="VALID">
          <orgName>Yale School of Medicine [New Haven, Connecticut]</orgName>
          <orgName type="acronym">YSM</orgName>
          <desc>
            <address>
              <addrLine>Yale University School of Medicine - 333 Cedar Street - New Haven, CT 06510</addrLine>
              <country key="US"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-302177" status="VALID">
          <idno type="IdRef">027216152</idno>
          <idno type="ISNI">0000000121671098</idno>
          <idno type="ROR">https://ror.org/000xsnr85</idno>
          <idno type="Wikidata">Q1232428</idno>
          <orgName>Universidad del País Vasco [Espainia] / Euskal Herriko Unibertsitatea [España] = University of the Basque Country [Spain] = Université du pays basque [Espagne]</orgName>
          <orgName type="acronym">UPV / EHU</orgName>
          <date type="start">1980-02-25</date>
          <desc>
            <address>
              <addrLine>Barrio Sarriena s/n, 48940 Leioa, BizkaiaCampus d'Álava : Vice-Rectorado, San Antonio 41, 01005 Vitoria ; campus de Biscaye et services centraux : Apdo 1397, 48080 Bilbao ; campus de Guipúzcoa : Vice-Rectorado, Fuenterrabia 13-1° , 20006 San Sebastián</addrLine>
              <country key="ES"/>
            </address>
            <ref type="url">http://www.ehu.eus/es/home</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1090097" status="VALID">
          <idno type="IdRef">192863495</idno>
          <idno type="RNSR">201521288D</idno>
          <idno type="ROR">https://ror.org/00bf6bf92</idno>
          <orgName>Oncogenesis, Stress, Signaling</orgName>
          <orgName type="acronym">OSS</orgName>
          <date type="start">2022-03-23</date>
          <desc>
            <address>
              <addrLine>Université de Rennes1 - CLCC Eugène Marquis, Rue de la Bataille Flandres Dunkerque, Bat D, 35042 Rennes</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://oss-clcc-rennes.com/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-105160" type="direct"/>
            <relation active="#struct-301510" type="direct"/>
            <relation active="#struct-502406" type="indirect"/>
            <relation name="u1242" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-301510" status="VALID">
          <idno type="ROR">https://ror.org/01yezas83</idno>
          <orgName>CRLCC Eugène Marquis</orgName>
          <orgName type="acronym">CRLCC</orgName>
          <desc>
            <address>
              <addrLine>Avenue Bataille Flandres-Dunkerque 35042 RENNES CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.centre-eugene-marquis.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-502406" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-1114557" status="VALID">
          <idno type="IdRef">238704718</idno>
          <idno type="ISNI">0000 0001 2181 4263</idno>
          <idno type="ROR">https://ror.org/01c27hj86</idno>
          <idno type="Wikidata">Q1122926</idno>
          <orgName>Universidade de Lisboa = University of Lisbon = Université de Lisbonne [Lisboa]</orgName>
          <orgName type="acronym">ULISBOA</orgName>
          <desc>
            <address>
              <addrLine>Alameda da Universidade 1649-004 Lisboa</addrLine>
              <country key="PT"/>
            </address>
            <ref type="url">https://www.ulisboa.pt/en</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-148408" status="VALID">
          <idno type="IdRef">026430584</idno>
          <idno type="ROR">https://ror.org/04jr1s763</idno>
          <orgName>Università degli Studi di Firenze = University of Florence = Université de Florence</orgName>
          <orgName type="acronym">UniFI</orgName>
          <desc>
            <address>
              <addrLine>Piazza di San Marco, 4, 50121 Firenze FI, Italie</addrLine>
              <country key="IT"/>
            </address>
            <ref type="url">https://www.unifi.it/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-308157" status="VALID">
          <idno type="ROR">https://ror.org/018906e22</idno>
          <orgName>Erasmus University Medical Center [Rotterdam]</orgName>
          <orgName type="acronym">Erasmus MC</orgName>
          <desc>
            <address>
              <addrLine>Rotterdam</addrLine>
              <country key="NL"/>
            </address>
            <ref type="url">http://www.erasmusmc.nl</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-452000" status="VALID">
          <idno type="IdRef">16726883X</idno>
          <idno type="ISNI">0000000085806601</idno>
          <idno type="ROR">https://ror.org/03j4zvd18</idno>
          <idno type="Wikidata">Q3152661</idno>
          <orgName>Università degli studi di Roma “Foro Italico” [Italia] = Foro Italico University of Rome [Italy] [Istituto Universitario di Scienze Motorie (UIMS) = University Institute of Motor Sciences]</orgName>
          <date type="start">1998-05-08</date>
          <desc>
            <address>
              <addrLine>Piazza Lauro de Bosis, 15 – 00135 Roma – Italia</addrLine>
              <country key="IT"/>
            </address>
            <ref type="url">http://www.uniroma4.it/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-336942" status="VALID">
          <idno type="ROR">https://ror.org/013czdx64</idno>
          <orgName>Heidelberg University Hospital [Heidelberg]</orgName>
          <desc>
            <address>
              <addrLine>Im Neuenheimer Feld 40069120 Heidelberg</addrLine>
              <country key="DE"/>
            </address>
            <ref type="url">http://www.heidelberg-university-hospital.com/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-3447" status="VALID">
          <idno type="ROR">https://ror.org/021018s57</idno>
          <orgName>Universitat de Barcelona</orgName>
          <orgName type="acronym">UB</orgName>
          <desc>
            <address>
              <addrLine>Gran Via de les Corts Catalanes, 585, 08007 Barcelona</addrLine>
              <country key="ES"/>
            </address>
            <ref type="url">http://www.ub.edu/web/ub/en</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-171924" status="VALID">
          <idno type="ISNI">0000 0004 5930 4607</idno>
          <idno type="ROR">https://ror.org/03cn6tr16</idno>
          <idno type="Wikidata">Q30296151</idno>
          <orgName>Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas =  Biomedical Research Network Center for Liver and Digestive Diseases [Madrid]</orgName>
          <orgName type="acronym">CIBERehd</orgName>
          <date type="start">2006-01-01</date>
          <desc>
            <address>
              <addrLine>Centro de Investigación Biomédica en Red, Instituto de Salud Carlos IIIC/ Monforte de Lemos 3-5.Pabellón 11. Planta 028029 Madrid</addrLine>
              <country key="ES"/>
            </address>
            <ref type="url">https://www.ciberehd.org/en</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301917" status="VALID">
          <idno type="ROR">https://ror.org/0008xqs48</idno>
          <orgName>Institut d'Investigació Biomèdica de Bellvitge = Bellvitge Biomedical Research Institute</orgName>
          <orgName type="acronym">IDIBELL</orgName>
          <date type="start">2004-01-01</date>
          <desc>
            <address>
              <addrLine>Avinguda de la Granvia, 199, 08908 L'Hospitalet de Llobregat, Barcelona</addrLine>
              <country key="ES"/>
            </address>
            <ref type="url">http://www.idibell.cat/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1040226" status="VALID">
          <orgName>The Christie NHS Foundation Trust [Manchester, Royaume-Uni]</orgName>
          <desc>
            <address>
              <country key="GB"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-121172" status="VALID">
          <idno type="IdRef">224790781</idno>
          <idno type="ROR">https://ror.org/027m9bs27</idno>
          <orgName>University of Manchester [Manchester]</orgName>
          <desc>
            <address>
              <addrLine>Oxford Rd, Manchester M13 9PL</addrLine>
              <country key="GB"/>
            </address>
            <ref type="url">http://www.manchester.ac.uk/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300875" status="VALID">
          <idno type="IdRef">029789753</idno>
          <idno type="ROR">https://ror.org/02jx3x895</idno>
          <orgName>University College London [UCL]</orgName>
          <orgName type="acronym">UCL</orgName>
          <desc>
            <address>
              <addrLine>Gower Street, London WC1E 6BT</addrLine>
              <country key="GB"/>
            </address>
            <ref type="url">http://www.ucl.ac.uk/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-310910" status="VALID">
          <orgName>Mayo Clinic</orgName>
          <desc>
            <address>
              <country key="US"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-157897" status="VALID">
          <idno type="ROR">https://ror.org/02qp3tb03</idno>
          <orgName>Mayo Clinic [Rochester]</orgName>
          <desc>
            <address>
              <addrLine>200 First St. SWRochester, MN 55905</addrLine>
              <country key="US"/>
            </address>
            <ref type="url">http://www.mayoclinic.org/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300499" status="VALID">
          <idno type="IdRef">026430053</idno>
          <idno type="ISNI">000000012187758X</idno>
          <idno type="ROR">https://ror.org/02f40zc51</idno>
          <orgName>Universidad de Salamanca [España] = University of Salamanca [Spain]</orgName>
          <date type="start">1218-01-01</date>
          <desc>
            <address>
              <addrLine>Patio de Escuelas 1, 37008 Salamanca. España</addrLine>
              <country key="ES"/>
            </address>
            <ref type="url">https://www.usal.es/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-460939" status="VALID">
          <idno type="IdRef">026458748</idno>
          <idno type="ROR">https://ror.org/035b05819</idno>
          <orgName>Københavns Universitet = University of Copenhagen = Université de Copenhague</orgName>
          <orgName type="acronym">UCPH</orgName>
          <date type="start">1479-01-01</date>
          <desc>
            <address>
              <addrLine>Nørregade 10, 1165 København, Danemark</addrLine>
              <country key="DK"/>
            </address>
            <ref type="url">http://www.ku.dk</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-229915" status="VALID">
          <idno type="IdRef">026430711</idno>
          <idno type="ROR">https://ror.org/02be6w209</idno>
          <orgName>Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome]</orgName>
          <orgName type="acronym">UNIROMA</orgName>
          <date type="start">1303-01-01</date>
          <desc>
            <address>
              <addrLine>Piazzale Aldo Moro 5, 00185 Roma</addrLine>
              <country key="IT"/>
            </address>
            <ref type="url">https://www.uniroma1.it/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-160788" status="VALID">
          <orgName>Universidad Pública de Navarra [Espagne] = Public University of Navarra</orgName>
          <orgName type="acronym">UPNA</orgName>
          <desc>
            <address>
              <addrLine>Campus de Arrosadia 31006 Pamplona</addrLine>
              <country key="ES"/>
            </address>
            <ref type="url">http://www.unavarra.es/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-190541" status="VALID">
          <idno type="ROR">https://ror.org/043mz5j54</idno>
          <orgName>University of California [San Francisco]</orgName>
          <orgName type="acronym">UC San Francisco</orgName>
          <desc>
            <address>
              <addrLine>505 Parnassus Ave, San Francisco, CA 94143</addrLine>
              <country key="US"/>
            </address>
            <ref type="url">https://www.ucsf.edu/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-471291" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-25887" status="VALID">
          <idno type="IdRef">02643184X</idno>
          <idno type="ISNI">000000012193314X</idno>
          <idno type="ROR">https://ror.org/00vtgdb53</idno>
          <orgName>University of Glasgow</orgName>
          <date type="start">1451-01-01</date>
          <desc>
            <address>
              <addrLine>Glasgow G12 8QQ Scotland</addrLine>
              <country key="GB"/>
            </address>
            <ref type="url">https://www.gla.ac.uk/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-541912" status="VALID">
          <idno type="RNSR">200918542V</idno>
          <orgName>Centre de Recherche Saint-Antoine</orgName>
          <orgName type="acronym">CRSA</orgName>
          <desc>
            <address>
              <addrLine>Bâtiment Kourilsky34 rue Crozatier75012 PARISSorbonne Université27 rue Chaligny75012 PARIS</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.crsa.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
            <relation name="U938" active="#struct-303623" type="direct"/>
            <relation name="UMRS_938" active="#struct-413221" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-105160" status="VALID">
          <idno type="IdRef">26693823X</idno>
          <idno type="ROR">https://ror.org/015m7wh34</idno>
          <orgName>Université de Rennes</orgName>
          <orgName type="acronym">UR</orgName>
          <desc>
            <address>
              <addrLine>Campus de Beaulieu, 263 avenue Général Leclerc, CS 74205, 35042 RENNES CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-rennes.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-502406" status="VALID">
          <orgName>UNICANCER</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75654 Paris Cedex 13</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.unicancer.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-471291" status="VALID">
          <idno type="ROR">https://ror.org/00pjdza24</idno>
          <orgName>University of California</orgName>
          <orgName type="acronym">UC</orgName>
          <date type="start">1869-01-01</date>
          <desc>
            <address>
              <country key="US"/>
            </address>
            <ref type="url">https://www.universityofcalifornia.edu/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300068" status="VALID">
          <idno type="ROR">https://ror.org/00pg5jh14</idno>
          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">AP-HP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-413221" status="VALID">
          <idno type="IdRef">221333754</idno>
          <idno type="ROR">https://ror.org/02en5vm52</idno>
          <orgName>Sorbonne Université</orgName>
          <orgName type="acronym">SU</orgName>
          <date type="start">2018-01-01</date>
          <desc>
            <address>
              <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.sorbonne-universite.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>