Acute and repeated impact of sweeteners and sweetness enhancers in solid and semi-solid foods on appetite: protocol for a multicentre, cross-over, RCT in people with overweight/obesity – the SWEET Project - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue BMJ Open Année : 2022

Acute and repeated impact of sweeteners and sweetness enhancers in solid and semi-solid foods on appetite: protocol for a multicentre, cross-over, RCT in people with overweight/obesity – the SWEET Project

Catherine Gibbons
Beverley O'Hara
Charo Hodgkins
Corey Scott
  • Fonction : Auteur
Louise Kjølbæk
Mie Normand
  • Fonction : Auteur
Ellen Blaak
Edith Feskens
  • Fonction : Auteur
Hariklia Moshoyiannis
  • Fonction : Auteur
Jason Halford
  • Fonction : Auteur
Kristine Beaulieu
Graham Finlayson

Résumé

Introduction Intake of free sugars in European countries is high and attempts to reduce sugar intake have been mostly ineffective. Non-nutritive sweeteners and sweetness enhancers (S&SEs) can maintain sweet taste in the absence of energy, but little is known about the impact of acute and repeated consumption of S&SE in foods on appetite. This study aims to evaluate the effect of acute and repeated consumption of two individual S&SEs and two S&SE blends in semisolid and solid foods on appetite and related behavioural, metabolic and health outcomes. Methods and analysis A work package of the SWEET Project; this study consists of five double-blind randomised cross-over trials which will be carried out at five sites across four European countries, aiming to have n=213. Five food matrices will be tested across three formulations (sucrose-sweetened control vs two reformulated products with S&SE blends and no added sugar). Participants (body mass index 25–35 kg/m 2 ; aged 18–60 years) will consume each formulation for 14 days. The primary endpoint is composite appetite score (hunger, inverse of fullness, desire to eat and prospective food consumption) over a 3-hour postprandial incremental area under the curve during clinical investigation days on days 1 and 14. Ethics and dissemination The trial has been approved by national ethical committees and will be conducted in accordance with the Declaration of Helsinki. Results will be published in international peer-reviewed open-access scientific journals. Research data from the trial will be deposited in an open-access online research data archive. Trial registration number NCT04633681 .
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Origine : Publication financée par une institution
Licence : CC BY NC - Paternité - Pas d'utilisation commerciale

Dates et versions

hal-03971097 , version 1 (11-04-2024)

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Catherine Gibbons, Beverley O'Hara, Dominic O’connor, Charlotte Hardman, Moon Wilton, et al.. Acute and repeated impact of sweeteners and sweetness enhancers in solid and semi-solid foods on appetite: protocol for a multicentre, cross-over, RCT in people with overweight/obesity – the SWEET Project. BMJ Open, 2022, 12 (12), pp.e063903. ⟨10.1136/bmjopen-2022-063903⟩. ⟨hal-03971097⟩
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