We consider a cross-layer scheme for the downlink multiuser Orthogonal Frequency Division Multiple Access (OFDMA) for mobile WiMAX (Worldwide Interoperability for Microwave Access) based on IEEE802.16e standard. We propose an intelligent Medium Access Control (MAC) that adapts with the physical layer (PHY) in response to the different QoS requirements of the diverse service flows in the system. This adaptation is represented by a joint packet scheduling and slot allocation scheme interaction in both MAC and PHY layers. Based on this interaction, a fair and efficient QoS guaranteed resource allocation for a mixture of real-time and non real-time service flows is achieved. We provide extensive simulation results showing the performance aspects of the proposed cross-layer scheme.