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Journal Articles ACS Nano Year : 2022

Programming Directed Motion with DNA-Grafted Particles

Abstract

Colloidal particles can be programmed to interact in complex ways by functionalizing them with DNA oligonucleotides. Adding DNA strand-displacement reactions to the system allows these interparticle interactions to respond to specific changes in temperature. We present the requirements for thermally-driven directed motion of colloidal particles, and we explore how these conditions can be realized experimentally using strand-displacement reactions. To evaluate the concept, we build and test a colloidal "dancer": a single particle that can be driven to move through a programmed sequence of steps along a one-dimensional track composed of other particles. The results of these tests reveal the capabilities and limitations of using DNA-mediated interactions for applications in dynamic systems. Specifically, we discuss how to design the substrate to 1 limit complexity while permitting full control of the motile component, how to ratchet the interactions to move over many substrate positions with a limited regime of control parameters, and ways to use new technological developments to reduce the probability of detachment without sacrificing speed.
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Dates and versions

hal-03967488 , version 1 (01-02-2023)

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Emily W Gehrels, W. Benjamin Rogers, Zorana Zeravcic, Vinothan N Manoharan. Programming Directed Motion with DNA-Grafted Particles. ACS Nano, 2022, 16 (6), pp.9195-9202. ⟨10.1021/acsnano.2c01454⟩. ⟨hal-03967488⟩
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