Patient-specific biokinetics and hybrid 2D/3D approach integration in OEDIPE software: application to radioiodine therapy
Résumé
Background The development of targeted radionuclide therapy requires the development of
dosimetry software accounting for patient-specific biokinetics. New functionalities were thus
developed in the OEDIPE software, to deal with multiple 3D images or multiple planar images
and a SPECT image.
Materiel & Method Methods were implemented to recover patient
biokinetics in volumes of interest. If several 3D SPECT images are available, they are registered
to a reference CT scan. When several planar images and a single SPECT are available, the
planar images are registered to the SPECT and counts of the planar images converted to
activity. To validate these developments, six SPECT/CT and planar images of a Jaszczak
phantom containing I-131 were acquired at different dates. Cumulated activity was estimated
in each sphere using the SPECT/CT images only or the planar series associated to one
SPECT/CT. Biokinetic and doses in lesions and in the lungs of a patient treated with I-131 for
differentiated thyroid cancer were then estimated using four planar images and a SPECT/CT
scan. Whole-body retention data were used to compare the biokinetics obtained from the
planar and SPECT data.
Results Activities and cumulated activities estimated using OEDIPE in
the phantom spheres agreed well with the reference values for both approaches. Results
obtained for the patient compared well with those derived from whole-body retention data.
Conclusion The implemented features allow automatic evaluation of patient-specific
biokinetics from different series of patient images, enabling patient-specific dosimetry
without the need for external software to estimate the cumulated activities in different VOIs.
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