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Article Dans Une Revue Biochimica et Biophysica Acta:Biomembranes Année : 2023

Interactions of cholesterol molecules with GPCRs in different states: A comparative analysis of GPCRs' structures

Résumé

GPCRs form a very large family of transmembrane proteins involved in a wide range of physiological functions. Some GPCRs have their activity affected by the presence of cholesterol either indirectly through changes in the physical properties of the membrane or directly by binding to the receptor. Thanks to recent advances in structural biology, many structures of GPCRs have been solved, 240 of which contain at least one cholesterol molecule or surrogate. This review lists the position of these molecules and provides a comparative analysis of the changes observed in the structures depending on the state of the receptor
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hal-03959335 , version 1 (13-10-2023)

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Christophe Moreau, Guillaume Audic, Laura Lemel, M Dolores García-Fernández, Katarzyna Nieścierowicz. Interactions of cholesterol molecules with GPCRs in different states: A comparative analysis of GPCRs' structures. Biochimica et Biophysica Acta:Biomembranes, 2023, 1865 (3), pp.184100. ⟨10.1016/j.bbamem.2022.184100⟩. ⟨hal-03959335⟩
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