Psychological and organizational literature has rarely considered materiality (Orlikowski, 2007), and especially space, as an integral part of organizational life and workplace individual and collective experience. Workspaces’ characteristics (in terms of layout, noise, light) are at best featured as components of the physical working conditions and studied in relation to occupational hazards, stress (Burke, 1988; Evans & Cohen, 1987) or job performance and satisfaction (Vischer, 2007). In the recent years, an increasing number of modern companies considers workspace design and layout as a mean to support and manage organizational change and knowledge-sharing amongst professionals and teams. This evolution in workspace design and management calls for more research in work and organizational psychology on space as embedded within activities and as an object of study in its own right (Ianeva, Ciobanu & Vacherand-Revel, 2016). This symposium gathers academics and practitioners and intends to open up a theoretical and methodological discussion on several critical issues related to the (re)design, the appropriation and management of work through workspaces. What are the theoretical frameworks and concepts relevant for understanding space in its psychological, social and organizational dimensions? How could the design of work environments effectively support professional activities? In what ways workspace design and organization could trigger learning processes and support competence development? Why space matters for work psychologists? The expected contribution of the symposium is twofold. First, it should provide a basis for a theoretical and epistemological debate amongst the contributors (work and organizational psychology, cultural-historical activity theory, French ergonomics, clinic of activity). Second, the presentations of empirical research and workplace interventions will highlight practical and workplace intervention-related issues.