Breast Cancer Incidence in Relation to Long-Term Low-Level Exposure to Air Pollution in the ELAPSE Pooled Cohort - Archive ouverte HAL
Article Dans Une Revue Cancer Epidemiology, Biomarkers and Prevention Année : 2023

Breast Cancer Incidence in Relation to Long-Term Low-Level Exposure to Air Pollution in the ELAPSE Pooled Cohort

Ulla Arthur Hvidtfeldt
Jie Chen
  • Fonction : Auteur
Sophia P. Rodopoulou
  • Fonction : Auteur
Maciej Strak
Kees de Hoogh
  • Fonction : Auteur
Zorana Andersen
Tom D. Bellander
  • Fonction : Auteur
Jørgen Brandt
Daniela Fecht
  • Fonction : Auteur
Francesco Forastiere
John Gulliver
  • Fonction : Auteur
Ole Hertel
  • Fonction : Auteur
Barbara H. Hoffmann
  • Fonction : Auteur
K. Katsouyanni
  • Fonction : Auteur
Matthias Ketzel
Boel Brynedal
  • Fonction : Auteur
Karin Leander
  • Fonction : Auteur
Petter L.S. Ljungman
  • Fonction : Auteur
Patrik K.E. Magnusson
Gabriele Nagel
  • Fonction : Auteur
Göran Pershagen
  • Fonction : Auteur
Debora Rizzuto
  • Fonction : Auteur
E. Samoli
Rina So
  • Fonction : Auteur
Massimo Stafoggia
A. Tjønneland
Roel C.H. Vermeulen
Wilhelmina Monique Verschuren
  • Fonction : Auteur
Gudrun Weinmayr
  • Fonction : Auteur
Kathrin Wolf
  • Fonction : Auteur
Jiawei Zhang
Emanuel Zitt
  • Fonction : Auteur
Bert Brunekreef
  • Fonction : Auteur
Gerard Hoek
  • Fonction : Auteur
Ole Raaschou-Nielsen

Résumé

BACKGROUND: Established risk factors for breast cancer include genetic disposition, reproductive factors, hormone therapy, and lifestyle-related factors such as alcohol consumption, physical inactivity, smoking, and obesity. More recently a role of environmental exposures, including air pollution, has also been suggested. The aim of this study, was to investigate the relationship between long-term air pollution exposure and breast cancer incidence. METHODS: We conducted a pooled analysis among six European cohorts (n = 199,719) on the association between long-term residential levels of ambient nitrogen dioxide (NO2), fine particles (PM2.5), black carbon (BC), and ozone in the warm season (O3) and breast cancer incidence in women. The selected cohorts represented the lower range of air pollutant concentrations in Europe. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level. RESULTS: During 3,592,885 person-years of follow-up, we observed a total of 9,659 incident breast cancer cases. The results of the fully adjusted linear analyses showed a HR (95% confidence interval) of 1.03 (1.00-1.06) per 10 μg/m³ NO2, 1.06 (1.01-1.11) per 5 μg/m³ PM2.5, 1.03 (0.99-1.06) per 0.5 10-5 m-1 BC, and 0.98 (0.94-1.01) per 10 μg/m³ O3. The effect estimates were most pronounced in the group of middle-aged women (50-54 years) and among never smokers. CONCLUSIONS: The results were in support of an association between especially PM2.5 and breast cancer. IMPACT: The findings of this study suggest a role of exposure to NO2, PM2.5, and BC in development of breast cancer.

Dates et versions

hal-03949585 , version 1 (20-01-2023)

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Citer

Ulla Arthur Hvidtfeldt, Jie Chen, Sophia P. Rodopoulou, Maciej Strak, Kees de Hoogh, et al.. Breast Cancer Incidence in Relation to Long-Term Low-Level Exposure to Air Pollution in the ELAPSE Pooled Cohort. Cancer Epidemiology, Biomarkers and Prevention, 2023, 32 (1), pp.105-113. ⟨10.1158/1055-9965.EPI-22-0720⟩. ⟨hal-03949585⟩
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