Mouse arterial wall imaging and analysis from synchrotron X-ray microtomography
Résumé
Vascular ageing is characterized by profound modifications of the large elastic arteries (mainly aorta), leading to consequences such as aneurysm formation. Age-related diseases can be precipitated by metabolic disorders, e.g. diabetes or chronic kidney diseases. Vascular diseases involve morphological changes of the arterial extracellular matrix, particularly remodelling of the elastic lamellae found in the wall. Synchrotron X-ray microtomography (μCT) gives access to images with a micrometric resolution. In the context of vascular imaging, this allows the study of structural properties of arterial walls, even for small animals such as the mouse.
Domaines
Informatique [cs]| Origine | Fichiers produits par l'(les) auteur(s) |
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