Two new tetrahydrofuran derivatives from the fungus Mucor spp. SNB-VECD11D isolated from the Chrysomelidae Acalymma bivittula - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Tetrahedron Letters Année : 2017

Two new tetrahydrofuran derivatives from the fungus Mucor spp. SNB-VECD11D isolated from the Chrysomelidae Acalymma bivittula

Résumé

Two new tetrahydrofuran derivatives, mucorinic acids A (1) and B (2) as well as the three known secondary metabolites dehydroabietic acid (3), Δ8-dihydroabietic acid (4) and 8pimarenic acid (5) were isolated from a solid culture of the fungus Mucor spp. isolated on insect Acalymma bivittula. The structure of these compounds was elucidated by analysis of NMR and MS spectroscopic data. Compounds were tested in antimicrobial and insecticidal assays. Dehydroabietic acid exhibited moderate larvicidal activity on Aedes aegypti larvae with 65% mortality at 10 ppm. Both new compounds 1 and 2 showed interesting antibacterial activity on Staphylococcus aureus and methicillin resistant S. aureus with MIC values in the 8-16 μg/ml.
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hal-03945393 , version 1 (18-01-2023)

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Seindé Touré, Isabelle Dusfour, Didier Stien, Véronique Eparvier. Two new tetrahydrofuran derivatives from the fungus Mucor spp. SNB-VECD11D isolated from the Chrysomelidae Acalymma bivittula. Tetrahedron Letters, 2017, 58 (38), pp.3727-3729. ⟨10.1016/j.tetlet.2017.08.031⟩. ⟨hal-03945393⟩
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