Designing the next-generation clinical care pathway for Alzheimer’s disease - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Nature Aging Année : 2022

Designing the next-generation clinical care pathway for Alzheimer’s disease

Rhoda Au
  • Fonction : Auteur
Soeren Mattke
Liana Apostolova
  • Fonction : Auteur
Christopher Chen
  • Fonction : Auteur
Susan de Santi
  • Fonction : Auteur
Peng Gao
  • Fonction : Auteur
Ricky Kurzman
  • Fonction : Auteur
Andrew J Saykin

Résumé

The reconceptualization of Alzheimer’s disease (AD) as a clinical and biological construct has facilitated the development of biomarker-guided, pathway-based targeted therapies, many of which have reached late-stage development with the near-term potential to enter global clinical practice. These medical advances mark an unprecedented paradigm shift and requires an optimized global framework for clinical care pathways for AD. In this Perspective, we describe the blueprint for transitioning from the current, clinical symptom-focused and inherently late-stage diagnosis and management of AD to the next-generation pathway that incorporates biomarker-guided and digitally facilitated decision-making algorithms for risk stratification, early detection, timely diagnosis, and preventative or therapeutic interventions. We address critical and high-priority challenges, propose evidence-based strategic solutions, and emphasize that the perspectives of affected individuals and care partners need to be considered and integrated.
Fichier principal
Vignette du fichier
NATURE AGING_Next-generation AD patient journey_2022.pdf (1.29 Mo) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-03942256 , version 1 (17-01-2023)

Identifiants

Citer

Harald Hampel, Rhoda Au, Soeren Mattke, Wiesje M van der Flier, Paul Aisen, et al.. Designing the next-generation clinical care pathway for Alzheimer’s disease. Nature Aging, 2022, 2, 2, pp.692 - 703. ⟨10.1038/s43587-022-00269-x⟩. ⟨hal-03942256⟩
17 Consultations
42 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More