The foundation and architecture of precision medicine in neurology and psychiatry - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Trends in Neurosciences Année : 2023

The foundation and architecture of precision medicine in neurology and psychiatry

Résumé

Neurological and psychiatric diseases have high degrees of genetic and pathophysiological heterogeneity, irrespective of clinical manifestations. Traditional medical paradigms have focused on late-stage syndromic aspects of these diseases, with little consideration of the underlying biology. Advances in disease modeling and methodological design have paved the way for the development of precision medicine (PM), an established concept in oncology with growing attention from other medical specialties. We propose a PM architecture for central nervous system diseases built on four converging pillars: multimodal biomarkers, systems medicine, digital health technologies, and data science. We discuss Alzheimer's disease (AD), an area of significant unmet medical need, as a casein-point for the proposed framework. AD can be seen as one of the most advanced PM-oriented disease models and as a compelling catalyzer towards PM-oriented neuroscience drug development and advanced healthcare practice. Conceptual overview of precision medicine
Fichier principal
Vignette du fichier
TRENDS IN NEUROSCIENCES_Precision Medicine in Neurology & Psychiatry_2022.pdf (2.5 Mo) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-03938895 , version 1 (14-01-2023)

Identifiants

Citer

Harald Hampel, Peng Gao, Jeffrey Cummings, Nicola Toschi, Paul M Thompson, et al.. The foundation and architecture of precision medicine in neurology and psychiatry. Trends in Neurosciences, In press, ⟨10.1016/j.tins.2022.12.004⟩. ⟨hal-03938895⟩
25 Consultations
100 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More