<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03936101</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-26T06:24:50+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Integrating the evidence in allergen immunotherapy: Why real-world data should be important for the practicing clinician?</title>
            <author role="crp">
              <persName>
                <forename type="first">Moises</forename>
                <forename type="middle">A.</forename>
                <surname>Calderon</surname>
              </persName>
              <email type="md5">6d59c838e3bc5e70686368ae16c2a55e</email>
              <email type="domain">imperial.ac.uk</email>
              <idno type="idhal" notation="numeric">933589</idno>
              <idno type="halauthorid" notation="string">983615-933589</idno>
              <affiliation ref="#struct-69530"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">P</forename>
                <surname>Demoly</surname>
              </persName>
              <email type="md5">23f02926435bb7bfb08293ddfbbdc588</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="string">pascal-demoly</idno>
              <idno type="idhal" notation="numeric">754222</idno>
              <idno type="halauthorid" notation="string">46486-754222</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/Y-9938-2019</idno>
              <idno type="IDREF">https://www.idref.fr/03442959X</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-7827-7964</idno>
              <idno type="GOOGLE SCHOLAR">http://scholar.google.fr/citations?user=So_kniIAAAAJ&amp;hl=fr</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/Y-9938-2019</idno>
              <affiliation ref="#struct-81964"/>
              <affiliation ref="#struct-1114331"/>
              <affiliation ref="#struct-1100793"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Mélanie</forename>
                <surname>KARLI</surname>
              </persName>
              <email type="md5">ede2b723a0c0ac40035aa4ead502961c</email>
              <email type="domain">umontpellier.fr</email>
            </editor>
            <funder>Funding support provided by ALK through an unrestricted educational grant to the American Association of Certified Allergists (AACA).</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2023-01-12 14:36:08</date>
              <date type="whenModified">2026-05-14 03:12:16</date>
              <date type="whenReleased">2023-01-12 14:36:09</date>
              <date type="whenProduced">2022-07-01</date>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="549666">
                <persName>
                  <forename>Mélanie</forename>
                  <surname>KARLI</surname>
                </persName>
                <email type="md5">ede2b723a0c0ac40035aa4ead502961c</email>
                <email type="domain">umontpellier.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03936101</idno>
            <idno type="halUri">https://hal.science/hal-03936101</idno>
            <idno type="halBibtex">calderon:hal-03936101</idno>
            <idno type="halRefHtml">&lt;i&gt;Allergy and Asthma Proceedings&lt;/i&gt;, 2022, 43 (4), pp.305-309. &lt;a target="_blank" href="https://dx.doi.org/10.2500/aap.2022.43.220006"&gt;&amp;#x27E8;10.2500/aap.2022.43.220006&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Allergy and Asthma Proceedings, 2022, 43 (4), pp.305-309. &amp;#x27E8;10.2500/aap.2022.43.220006&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INRIA">INRIA - Institut National de Recherche en Informatique et en Automatique</idno>
            <idno type="stamp" n="INRIA-SOPHIA">INRIA Sophia Antipolis - Méditerranée</idno>
            <idno type="stamp" n="INRIASO">INRIA-SOPHIA</idno>
            <idno type="stamp" n="INRIA_TEST">INRIA - Institut National de Recherche en Informatique et en Automatique</idno>
            <idno type="stamp" n="INRIA34">Antenne Inria de l'université de Montpellier</idno>
            <idno type="stamp" n="TESTALAIN1">TESTALAIN1</idno>
            <idno type="stamp" n="INRIA2">INRIA 2</idno>
            <idno type="stamp" n="UNIV-MONTPELLIER">Université de Montpellier</idno>
            <idno type="stamp" n="IDESP">Institut Desbrest d’Épidémiologie et de Santé Publique</idno>
            <idno type="stamp" n="UM-2015-2021" corresp="UNIV-MONTPELLIER">Université de Montpellier (2015-2021)</idno>
            <idno type="stamp" n="UM-EPE" corresp="UNIV-MONTPELLIER">Université de Montpellier - EPE</idno>
            <idno type="stamp" n="INRIA-ROYAUMEUNI">INRIA-ROYAUMEUNI</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Integrating the evidence in allergen immunotherapy: Why real-world data should be important for the practicing clinician?</title>
                <author role="crp">
                  <persName>
                    <forename type="first">Moises</forename>
                    <forename type="middle">A.</forename>
                    <surname>Calderon</surname>
                  </persName>
                  <email type="md5">6d59c838e3bc5e70686368ae16c2a55e</email>
                  <email type="domain">imperial.ac.uk</email>
                  <idno type="idhal" notation="numeric">933589</idno>
                  <idno type="halauthorid" notation="string">983615-933589</idno>
                  <affiliation ref="#struct-69530"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">P</forename>
                    <surname>Demoly</surname>
                  </persName>
                  <email type="md5">23f02926435bb7bfb08293ddfbbdc588</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="string">pascal-demoly</idno>
                  <idno type="idhal" notation="numeric">754222</idno>
                  <idno type="halauthorid" notation="string">46486-754222</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/Y-9938-2019</idno>
                  <idno type="IDREF">https://www.idref.fr/03442959X</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-7827-7964</idno>
                  <idno type="GOOGLE SCHOLAR">http://scholar.google.fr/citations?user=So_kniIAAAAJ&amp;hl=fr</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/Y-9938-2019</idno>
                  <affiliation ref="#struct-81964"/>
                  <affiliation ref="#struct-1114331"/>
                  <affiliation ref="#struct-1100793"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">10342</idno>
                <idno type="issn">1088-5412</idno>
                <idno type="eissn">1539-6304</idno>
                <title level="j">Allergy and Asthma Proceedings</title>
                <imprint>
                  <publisher>OceanSide Publications; 1999</publisher>
                  <biblScope unit="volume">43</biblScope>
                  <biblScope unit="issue">4</biblScope>
                  <biblScope unit="pp">305-309</biblScope>
                  <date type="datePub">2022-07-01</date>
                </imprint>
              </monogr>
              <idno type="doi">10.2500/aap.2022.43.220006</idno>
              <idno type="pubmed">35818147</idno>
              <idno type="wos">000829087000011</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="mesh">Allergens</classCode>
              <classCode scheme="mesh">Antigens, Dermatophagoides</classCode>
              <classCode scheme="mesh">Asthma</classCode>
              <classCode scheme="mesh">Desensitization, Immunologic</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">Retrospective Studies</classCode>
              <classCode scheme="mesh">Rhinitis, Allergic</classCode>
              <classCode scheme="halDomain" n="sdv.mhep">Life Sciences [q-bio]/Human health and pathology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Data obtained from controlled clinical trials are the gold standard for evaluation of allergen immunotherapy (AIT) efficacy and safety. Less prone to biases (with a strong internal validity), they allow their use and external validation in the real world. The quantity and diversity of real-world data has increased exponentially, and access to large cohorts and electronic medical records have made this information increasingly accessible and useful for research and regulatory purposes. New retrospective database studies have confirmed the sustained benefits of grass, birch pollen, and house dust mite AIT for both allergic rhinitis and asthma symptom and medication scores, the prevention of asthma (when used in nonasthmatic rhinitics), and the real rate of adverse systemic reactions. They also have addressed clinical practice issues not elsewhere analyzed, including the management of polysensitized patients with respiratory allergies and adherence to AIT. Real-world evidence has its own biases and limits that need to be taken into account. In this article we present a concise summary of the literature about the role of real-world evidence in AIT.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-69530" status="VALID">
          <idno type="ISNI">0000000121138111</idno>
          <idno type="ROR">https://ror.org/041kmwe10</idno>
          <orgName>Imperial College London</orgName>
          <date type="start">1907-01-01</date>
          <desc>
            <address>
              <addrLine>South Kensington Campus, London SW7 2AZ</addrLine>
              <country key="GB"/>
            </address>
            <ref type="url">http://www.imperial.ac.uk/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-81964" status="VALID">
          <orgName>Département pneumologie et addictologie [Montpellier]</orgName>
          <desc>
            <address>
              <addrLine>371, av. du Doyen Gaston Giraud 34295 Montpellier cedex 5</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300143" type="direct"/>
            <relation active="#struct-258773" type="indirect"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-1114331" status="VALID">
          <idno type="RNSR">202224287H</idno>
          <idno type="ROR">https://ror.org/050y2w676</idno>
          <orgName>Médecine de précision par intégration de données et inférence causale</orgName>
          <orgName type="acronym">PREMEDICAL</orgName>
          <date type="start">2022-06-01</date>
          <date type="end">2026-09-30</date>
          <desc>
            <address>
              <addrLine>860 Rue de St - Priest, 34090 Montpellier</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-34586" type="direct"/>
            <relation active="#struct-300009" type="indirect"/>
            <relation active="#struct-1100793" type="direct"/>
            <relation name="UA 11 / U1318" active="#struct-303623" type="indirect"/>
            <relation active="#struct-1100589" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1100793" status="VALID">
          <idno type="RNSR">202123741U</idno>
          <idno type="ROR">https://ror.org/01dwzy755</idno>
          <orgName>Institut Desbrest d'Epidémiologie et de Santé Publique</orgName>
          <orgName type="acronym">IDESP</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <addrLine>Institut Universitaire de Recherche Clinique641 Avenue du Doyen Gaston Giraud34093 Montpellier</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="UA 11 / U1318" active="#struct-303623" type="direct"/>
            <relation active="#struct-1100589" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300143" status="VALID">
          <idno type="ISNI">000000010507738X</idno>
          <idno type="ROR">https://ror.org/04m6sq715</idno>
          <orgName>Hôpital Arnaud de Villeneuve [CHU Montpellier]</orgName>
          <desc>
            <address>
              <addrLine>371 avenue du Doyen Gaston Giraud - 34090 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-montpellier.fr/fr/a-propos-du-chu/decouvrir/etablissements/arnaud-de-villeneuve</ref>
          </desc>
          <listRelation>
            <relation active="#struct-258773" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-258773" status="VALID">
          <idno type="ISNI">000000009961060X</idno>
          <idno type="ROR">https://ror.org/04m6sq715</idno>
          <orgName>Centre Hospitalier Régional Universitaire [Montpellier]</orgName>
          <orgName type="acronym">CHRU Montpellier</orgName>
          <desc>
            <address>
              <addrLine>191 avenue du doyen Gaston Giraud 34295 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-montpellier.fr/fr/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-34586" status="VALID">
          <idno type="RNSR">198318250R</idno>
          <idno type="ROR">https://ror.org/01nzkaw91</idno>
          <orgName>Centre Inria d'Université Côte d'Azur</orgName>
          <desc>
            <address>
              <addrLine>2004 route des Lucioles BP 93 06902 Sophia Antipolis</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inria.fr/centre/sophia/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300009" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300009" status="VALID">
          <idno type="ROR">https://ror.org/02kvxyf05</idno>
          <orgName>Institut National de Recherche en Informatique et en Automatique</orgName>
          <orgName type="acronym">Inria</orgName>
          <desc>
            <address>
              <addrLine>Domaine de VoluceauRocquencourt - BP 10578153 Le Chesnay Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inria.fr/en/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-1100589" status="VALID">
          <idno type="ROR">https://ror.org/051escj72</idno>
          <orgName>Université de Montpellier</orgName>
          <orgName type="acronym">UM</orgName>
          <date type="start">2022-01-01</date>
          <desc>
            <address>
              <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.umontpellier.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>