<i>In vitro</i> Applications of the Terpene Mini‐Path 2.0 - Archive ouverte HAL Access content directly
Journal Articles ChemBioChem Year : 2022

In vitro Applications of the Terpene Mini‐Path 2.0

Hayat Hage
  • Function : Author
  • PersonId : 1036180
Marc Maresca


In 2019 four groups reported independently the development of a simplified enzymatic access to the diphosphates (IPP and DMAPP) of isopentenol and dimethylallyl alcohol (IOH and DMAOH). The former are the two universal precursors of all terpenes. We report here on an improved version of what we call the terpene mini-path as well as its use in enzymatic cascades in combination with various transferases. The goal of this study is to demonstrate the in vitro utility of the TMP in, i) synthesizing various natural terpenes, ii) revealing the product selectivity of an unknown terpene synthase, or iii) generating unnatural cyclobutylated terpenes.
Fichier principal
Vignette du fichier
Couillaud et al ChemBioChem.pdf (1.25 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive

Dates and versions

hal-03935973 , version 1 (13-01-2023)



Julie Couillaud, Agnès Amouric, Elise Courvoisier-Dezord, Létitia Leydet, Nicolas Schweitzer, et al.. In vitro Applications of the Terpene Mini‐Path 2.0. ChemBioChem, 2022, 23 (24), pp.e202200595. ⟨10.1002/cbic.202200595⟩. ⟨hal-03935973⟩
116 View
90 Download



Gmail Facebook X LinkedIn More